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首页> 外国专利> N-(PIPERIDINYL-1-ALKYL)-SUBSTITUTED CYCLOHEXANE CAN-(PIPERIDINYL-1-ALKYL)-SUBSTITUTED CYCLOHEXANE CARBOXYLIC ACID AMIDES AS 5-HT1A RECEPTOR ANTAGONISTRBOXYLIC ACID AMIDES AS 5-HT1A RECEPTOR ANTAGONISTS S

N-(PIPERIDINYL-1-ALKYL)-SUBSTITUTED CYCLOHEXANE CAN-(PIPERIDINYL-1-ALKYL)-SUBSTITUTED CYCLOHEXANE CARBOXYLIC ACID AMIDES AS 5-HT1A RECEPTOR ANTAGONISTRBOXYLIC ACID AMIDES AS 5-HT1A RECEPTOR ANTAGONISTS S

机译：N-（哌啶基-1-烷基）取代的环己烷CAN-（哌啶基-1-烷基）取代的环己基羧酸酰胺作为5-HT1A受体拮抗剂羧酸酰胺作为5-HT1A受体拮抗剂S

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摘要

Compounds of formula (I) and the pharmaceutically acceptable acid addition salts thereof are 5-HT binding agents and may be used, for example, as anxiolytics. In the formula a and b each represents 0, 1, 2 or 3 such that the sum of a + b is 0, 1, 2 or 3, the dotted line represents an optional double bond which may be present in the ring, provided that a is at least 1, A is an alkylene chain of 1 or 2 carbon atoms optionally substituted by one or more lower alkyl groups, R is a mono or bicyclic aryl or heteroaryl radical with the proviso that R is not an unsubstituted phenyl group, R1 is a mono or bicyclic heteroaryl radical, and R2 is cycloalkyl or cycloalkenyl.
机译：式（I）的化合物及其药学上可接受的酸加成盐是5-HT结合剂，并且可以用作例如抗焦虑药。式中a和b分别表示0、1、2或3，以使a + b的总和为0、1、2或3，虚线表示环中可能存在的可选双键，条件是a为至少1，A为1或2个碳原子的亚烷基链，可选地被一个或多个低级烷基取代，R为单环或双环芳基或杂芳基，条件是R不是未取代的苯基，R1 R 1为单环或双环杂芳基，R 2为环烷基或环烯基。

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