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Dispersible cimetidine tablets

机译：西咪替丁分散片

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摘要

There are described novel dispersible cimetidine tablets containing 30 to 90 % by weight of one of the polymorphous modifications of cimetidine A, B or C, 5 to 55 % by weight of one or more disintegrationg agents, 0.05 to 5.0 % by weight of a surfactant, such as sodium lauryl sulphate together with other common adjuvants. The process for the manufacture of dispersible cimetidine tablets is effected on the basis of known methods by granulating the ingredients and by compressing the granulate to tablets. Dispersible tablets disintegrate when brought in contact with water at room temperature within less than 1 minute to yield a fine dispersion, which facilitates the oral application. Therefore such tablets are particularly suitable for certain groups of patients, especiallly for the aged and children. Dispersible tablets containing cimetidine excell by their improved rate of dissolution and good bioavailability.

机译：描述了新颖的可分散的西咪替丁片剂，其包含30至90重量％的西咪替丁A，B或C的多晶型变体之一，5至55重量％的一种或多种崩解剂，0.05至5.0重量％的表面活性剂。，例如十二烷基硫酸钠和其他常见的佐剂。可分散的西咪替丁片剂的制造方法是根据已知方法通过将成分制粒并将颗粒压制成片剂来进行的。当在室温下在不到1分钟的时间内与水接触时，可分散片剂会崩解，从而产生精细的分散液，从而有利于口服。因此，这种片剂特别适用于某些患者群体，尤其是老年人和儿童。含有西咪替丁excell的分散片具有更高的溶出速率和良好的生物利用度。

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公开/公告号JPH0791182B2

专利类型
公开/公告日1995-10-04

原文格式PDF
申请/专利权人 RETSUKU TOBARUNA FUARUMASEBUTOSUKII IN KEMIKUNII IJERUKOBU;
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申请/专利号JP19890158453
发明设计人 MATEYA KOASHITSUKU;JENII MIROATSUKU;HORONA CHERUBARU;ANTON SUTARUKU;TSUETSUDANA TOROSUTO;TSUDORAUKO KOPITARU;BOYAN KOFURAA;UIDA NIKORITSUKU;MARYA RANPURETO;MARYA RIPAI;
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申请日1989-06-22
分类号A61K9/20;A61K31/415;
国家 JP
入库时间 2022-08-22 04:27:11

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