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Vis-a-vis the cell poisonous operation of the human immunity incomplete virus effective Acid stability jideokishinukureoshido
Vis-a-vis the cell poisonous operation of the human immunity incomplete virus effective Acid stability jideokishinukureoshido
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机译：对人免疫力不完全病毒有效的细胞毒性操作酸稳定性jideokishinukureoshido
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摘要
2'3,'-dideoxynucleosides which are effective in inhibiting the infectivity of the human immunodeficiency virus and which are stable in an acidic environment are disclosed, which compounds conform to the formula: CHEM wherein X is selected from the group consisting of hydrogen, F, CN, N3 and NO2; Y is either H or F; with the proviso that Y is F only when X=H. Also disclosed is a compound of the formula: CHEM Also disclosed are compounds conforming to the formula: CHEM wherein R may be either OH or NH2; and L is NH2. Also disclosed are compounds conforming to the formula: CHEM wherein A is selected from the group consisting of OH and NH2 B is selected from the group consisting of H, CH3, CF3, CH=CHBr, and halogen.
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