SUSTAINED RELEASE PHARMACEUTICAL PREPARATIONS HAVING pH CONTROLLED MEMBRANE COATINGS
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机译：具有pH控制的膜涂层的持续释放药物制剂
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摘要
the invention relates to a pharmaceutical preparation for sustained release, membrane diffusion controlled by ph, which is composed of a ph sensitive polymer film former.the polymer may be a polymer film forming water containing phthalic acid, a carboxyl group is fixed in the enteric polymer through an ester linkage to the second carboxyl group remains a free acid and the polymer forming, as amended, is hydroph hydrophilic obe to low ph and at high ph values.the side chains of hydrophobic stearyl are laid down in the enteric polymer, so that the membrane is regulated by the ph distribution solution at high ph values.in another embodiment, the polynu00e8re forming ph sensitive may be a polymer containing acid groups and a hydrophobic polymer, so that the film forming modified hydrophobic and hydrophilic at low ph, but insoluble at high ph values.in the pharmaceutical preparation for sustained release polymer forming is preferred, the drug coated on particles, forming a core in order to produce a membrane diffusion controlled by the ph of the product as the core, and the form of the microparticles. can be mixed with a drug or a drug to be released over time.and placed in a gelatin capsule or made into tablets.
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