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首页> 外文会议>Proceedings '96 China-Japan symjposium on particuology >SPOUTED-BED COATING OF FINE PHARMACEUTICAL POWDERS WITH COMPOSITE LATICES FOR PREPARATION OF CONTROLLED RELEASE SYSTEMS
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SPOUTED-BED COATING OF FINE PHARMACEUTICAL POWDERS WITH COMPOSITE LATICES FOR PREPARATION OF CONTROLLED RELEASE SYSTEMS

机译：带有复杂晶格的精细药物粉末喷丸涂层，用于制备受控释放系统

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摘要

An aqueous composite latex, composed of a poly(EA/MMA/HEMA) core and a thermosensitive poly(NIPAAm) shell, was developed as a coating material for subsieve-sized particles in the Wurster process. This latex suppressed particle adhesion by electro-static charge and agglomeration in coating, and exhibited self-film-formability in dissolution. Microcapsules coated with composite latices showed a temperature-sensitive release of water-soluble lactose. When they were exposed to a critical temperature around LCST during the dissolution process, the lactose release from them was most suppressed, suggesting that shrinkage of the dehydrated poly(NIPAAm) shells in the coat of the microcapsules at the critical temperature would contribute to formation of a compact film which could strongly suppress water- and lactose-permeation. This type of microcapsule membrane also exhibited a controlled release of water-soluble polymer, dextran,, corresponding to release rate of incorporated lactose.
机译：开发了一种水性复合胶乳，该胶乳由聚（EA / MMA / HEMA）核和热敏聚（NIPAAm）壳组成，作为Wurster工艺中用于筛分大小颗粒的涂料。该胶乳通过静电电荷和涂层中的团聚抑制了颗粒的粘附，并且在溶解中表现出自成膜性。用复合胶乳包被的微胶囊显示出水溶性乳糖的温度敏感释放。当它们在溶解过程中暴露于LCST附近的临界温度时，从其中释放的乳糖受到最大抑制，这表明在临界温度下微胶囊涂层中脱水的聚（NIPAAm）壳的收缩将有助于形成可以强烈抑制水和乳糖渗透的致密膜。这种微囊膜还表现出水溶性聚合物右旋糖酐的受控释放，对应于掺入乳糖的释放速率。

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