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Marker for early detection of human hydatidiform moles and choriocarcinomas

机译：早期发现人葡萄胎和绒毛膜癌的标记

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摘要

The present invention relates to a DNA segment comprising linked pregnancy-specific beta.sub.1 -glycoprotein (PS&bgr;G) genes encoding PSGGA protein and PSGGB protein. The invention further relates to a probe (DNA, RNA or peptide probe) specific for PSGGB mRNA or protein expressed in human hydatidiform molar trophoblastic tissue and to a bioassay for the detection of gestational trophoblastic diseases. The PSGGB-specific probes of the present invention hybridized most strongly with RNA from molar trophoblastic tissue, suggesting that the PSGGB-like species may be the gene preferentially expressed in gestational trophoblastic diseases.

机译：本发明涉及一种DNA片段，其包含编码PSGGA蛋白和PSGGB蛋白的连接的怀孕特异性β1-糖蛋白（PS＆bgrG）基因。本发明进一步涉及对在人葡萄胎状磨牙滋养细胞组织中表达的PSGGB mRNA或蛋白质具有特异性的探针（DNA，RNA或肽探针），并且涉及用于检测妊娠滋养细胞疾病的生物测定。本发明的PSGGB特异性探针与来自磨牙滋养细胞组织的RNA最强烈地杂交，表明PSGGB样物种可能是在妊娠滋养细胞疾病中优先表达的基因。

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公开/公告号US5141849A

专利类型
公开/公告日1992-08-25

原文格式PDF
申请/专利权人 THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES;
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申请/专利号US19900536101
发明设计人 JANICE CHOU;
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申请日1990-06-08
分类号C12Q1/68;G01N33/53;A61K37/02;C07H15/12;
国家 US
入库时间 2022-08-22 05:22:26

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