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Histomolecular characterization of human hydatidiform moles: Distinguishing complete moles from partial moles.

机译：人葡萄胎的组织分子表征：将部分痣与部分痣区分开。

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Hydatidiform moles (HMs) are classified as partial or complete based on a combination of gross, histologic, and karyotypic features. Adherence to strict and reproducible diagnostic criteria is needed to ensure accurate diagnosis by minimizing pathological dilemmas when dealing with the variabilities encountered with molar pregnancies. This controversy has resulted from moles being evacuated at earlier stages when classical features are not yet developed. Also, it still remains unclear why Complete Moles (CMs) have a greater tendency to develop into malignant choriocarcinoma as compared with the Partial Moles (PMs). Optimal management of patients dictates diagnostic accuracy in differentiating CMs from PMs in the treatment and prognosis of patient care, but is not achieved always.; In conclusion, this study revealed the utility of image analysis in paraffin sections for the determination of DNA ploidy status of molar pregnancies and should be used in combination with histological and immunohistchemical methods for diagnostic accuracy. (Abstract shortened by UMI.)

机译：葡萄胎（HMs）根据总体，组织学和核型特征的组合分为部分或全部。需要坚持严格和可重复的诊断标准，以确保在处理磨牙妊娠的变异时最大程度地减少病理难题，从而确保准确的诊断。引起争议的原因是，在尚未开发出经典功能的较早阶段将痣撤离。同样，仍不清楚为什么全痣（CMs）与部分痣（PMs）相比有更大的发展为恶性绒癌的趋势。病人的最佳管理决定了在治疗和预后护理方面将CM与PM区别开来的诊断准确性，但并非总是如此。总之，这项研究揭示了石蜡切片中图像分析在确定磨牙妊娠的DNA倍性状态中的实用性，并应与组织学和免疫组织化学方法结合使用以提高诊断的准确性。（摘要由UMI缩短。）

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作者
Tewari, Rachel R.;
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作者单位

Adelphi University.;

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授予单位 Adelphi University.;
学科 Health Sciences Pathology.; Biology Cell.; Biology Genetics.
学位 M.S.
年度 2003
页码 86 p.
总页数 86
原文格式 PDF
正文语种 eng
中图分类病理学;细胞生物学;遗传学;
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专利

1. In patients with neoplasia after partial hydatidiform mole immunohistochemistry or genotyping is essential to differentiate partial hydatidiform mole from complete mole, histologic examination is insufficient. [J] . Ernest I Kohorn International journal of gynecological cancer: official journal of the International Gynecological Cancer Society . 2014,第9期

机译：在部分葡萄胎后葡萄膜瘤患者中，免疫组化或基因分型对于区分葡萄胎部分葡萄胎与完全葡萄胎至关重要，组织学检查不足。
2. Mutations in NLRP7 are associated with diploid biparental hydatidiform moles, but not androgenetic complete moles. [J] . Peter H Dixon, Pirada Trongwongsa, Shadi Abu-Hayyah, Journal of Medical Genetics . 2012,第3期

机译：NLRP7中的突变与二倍体双亲葡萄胎相似，而与雄激素完全性葡萄胎无关。
3. Heterogeneity in the origin of recurrent complete hydatidiform moles: not all women with multiple molar pregnancies have biparental moles. [J] . van der Smagt JJ, Scheenjes E, Kremer JA, BJOG: an international journal of obstetrics and gynaecology . 2006,第6期

机译：反复性完全葡萄胎的起源是异质性的：并非所有有多次磨牙妊娠的女性都有双亲痣。
4. Preeclampsia Complicating Early Pregnancy Period in a Case of Partial Hydatidiform Mole [C] . M. Cerna, M. Korbel, Z. Niznanska, European Congress of Perinatal Medicine . 2006

机译：在部分岩白鼹鼠的情况下，预填充剂复杂的早期妊娠期
5. Human-wildlife interactions, nature-based tourism, and protected areas management: The case of Mole National Park and the adjacent communities in Ghana. [D] . Acquah, Emmanuel. 2013

机译：人与野生动物的互动，基于自然的旅游和保护区管理：以摩尔国家公园和加纳附近社区为例。
6. Hydatidiform mole: parental chromosome aberrations in partial and complete moles. [O] . L O Vejerslev, R A Fisher, U Surti, 1987

机译：葡萄胎：双亲和部分痣的父母染色体畸变。
7. Hydatidiform mole: parental chromosome aberrations in partial and complete moles. [O] . Vejerslev, L O, Fisher, R A, Surti, U, 1987

机译：葡萄胎：双亲和部分痣的父母染色体畸变。

Histomolecular characterization of human hydatidiform moles: Distinguishing complete moles from partial moles.

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