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首页> 外文期刊>BJOG: an international journal of obstetrics and gynaecology >Heterogeneity in the origin of recurrent complete hydatidiform moles: not all women with multiple molar pregnancies have biparental moles.
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Heterogeneity in the origin of recurrent complete hydatidiform moles: not all women with multiple molar pregnancies have biparental moles.

机译：反复性完全葡萄胎的起源是异质性的：并非所有有多次磨牙妊娠的女性都有双亲痣。

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摘要

Hydatidiform moles of two women, each with three molar pregnancies, were examined in order to study their origin. Multiple recurrences have previously been associated with women who have biparental complete hydatidiform moles (CHM). However, all the moles examined in this study were androgenetic CHM (AnCHM), indicating that recurrent (>2) moles, particularly in the absence of a positive family history, may be androgenetic rather than biparental. These data suggest that some women have a specific liability for having AnCHM. Making the distinction between a biparental or an androgenetic origin of recurrent moles is of relevance for counselling and when considering therapeutic options. Therefore, we propose that all recurrent moles should be investigated using molecular techniques.
机译：检查了两名女性的葡萄胎，每胎有三个磨牙妊娠，以研究其起源。先前曾有双亲完全性葡萄胎（CHM）的妇女多次复发。但是，在这项研究中检查的所有痣都是雄激素性CHM（AnCHM），表明复发性（> 2）痣，尤其是在没有阳性家族史的情况下，可能是雄激素性而非双亲性的。这些数据表明，某些妇女对AnCHM有特殊的责任。区分复发性痣的双亲或雄激素起源与咨询和考虑治疗选择时有关。因此，我们建议应使用分子技术研究所有复发性痣。

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