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DNA probe which reveals a hypervariable region on human chromosome 19
DNA probe which reveals a hypervariable region on human chromosome 19
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机译：揭示人类19号染色体上高变区的DNA探针
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摘要
A DNA probe p13-1-25 is homologous to at least a portion of a hypervariable DNA region located on chromosome 19p13.2→19cen in the human genome. The DNA region displays extensive restrictive fragment length polymorphisms when digested with certain restriction endonucleases. Probe p13-1-25 is believed to have three closely linked lock (&agr;, . phi., &egr;). Loci &agr; and &phgr; each have two common alleles, whereas &egr; has at least 33 alleles, including a null allele. Unrelated individuals display unique fragment patterns on TaqI blots probed with p13-1-25. The probe can be used to produce a genetic "fingerprint" for establishing human identity, determining engraftment of bone marrow transplants, determining parentage, and otherwise mapping genes.
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