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CLONING OF THE BIOSYNTHETIC PATHWAY GENES FOR¹CHLORTETRACYCLINE PRODUCTION FROM STREPTOMYCES AUREOFACIENS¹amp; THEIR EXPRESSION IN STREPTOMYCES LIVIDANS
CLONING OF THE BIOSYNTHETIC PATHWAY GENES FOR¹CHLORTETRACYCLINE PRODUCTION FROM STREPTOMYCES AUREOFACIENS¹amp; THEIR EXPRESSION IN STREPTOMYCES LIVIDANS
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机译:产金黄色链霉菌¹的氯曲霉素的生物合成途径基因的克隆及其在利维链霉菌中的表达
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摘要
The present invention relates to the cloning, isolation and DNA (isolated fragment from Streptomyces aureofaciens) which directs the synthesis of tetracycline and chlortetracycline, in a heterologous host such as Streptomyces lividans. The claimed plasmids are isolated by screening a cosmid library, constructed in Escherichia coli, for the expression of tetracycline resistance in S. lividans.
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