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MUTATED PROMOTER REGION FROM CHICKEN SKELETAL ALPHA-ACTIN GENE
MUTATED PROMOTER REGION FROM CHICKEN SKELETAL ALPHA-ACTIN GENE
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机译：鸡骨骼肌α-肌动蛋白基因的启动子突变区
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摘要
A mutated skeletal actin promoter which differs from the naturally occurring DNA sequence by nucleotide substitution has been found to increase gene expression. The mutation sites are specific to the cis-acting regions of the gene. Double mutations created a strong promoter. Transformed myogenic cells had ten times the transcriptional activity over the wild type. The mutated skeletal actin promoter can be used to overly express polypeptides, particularly in myogenic cells.
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