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ANTIHERPES TETRAPEPTIDE DERIVATIVES HAVING A SUBSTITUTED ASPARTIC ACID SIDE CHAIN

机译:具有取代的戊二酸侧链的抗老四肽衍生物

摘要

Disclosed herein are tetrapeptide derivatives of the formula X-NH-CHR1-C(W1)-NR2-CH[CH2C(O)-Y]-C(W2)-NH-CH[CR3(R4)-COOH ]-C(W3)- NH -C HR 5- Z wherein X is a terminal group, for example, alkanoyl or phenylalkanoyl radicals, R1 and R5 are selected from amino acid or derived amino acid residues, R2 is hydrogen, alkyl or phenylalkyl, R3 and R4 are hydrogen or alkyl or R3 and R4 are joined to form a cycloalkyl, W1, W2 and W3 are oxo or thioxo, Y is, for example, an alkoxy or a monosubstituted or disubstituted amino, and Z is a terminal unit, for example, hydrogen, COOH or CH2OH. The derivatives are useful for treating herpes infections.
机译:本文公开了式X-NH-CHR 1 -C(W 1)-NR 2 -CH [CH 2 C(O)-Y] -C(W 2)-NH-的四肽衍生物CH [CR 3(R 4)-COOH] -C(W 3)-NH -C HR 5 -Z其中X是末端基,例如,烷酰基或苯基烷酰基,R < 1和R 5选自氨基酸残基或衍生的氨基酸残基,R 2是氢,烷基或苯基烷基,R 3和R 4是氢或烷基或R 3和R 5 4结合形成环烷基,W 1,W 2和W 3为氧代或硫代氧,Y为例如烷氧基或单取代或二取代的氨基,Z为末端单元,例如,氢,COOH或CH2OH。所述衍生物可用于治疗疱疹感染。

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