首页> 外国专利> For the marker genes of colorectal cancer classification, the method for the lymphatic metastasis of the gastric cancer for judging the prognosis for colorectal cancer and its external member

For the marker genes of colorectal cancer classification, the method for the lymphatic metastasis of the gastric cancer for judging the prognosis for colorectal cancer and its external member

机译:对于结直肠癌分类的标记基因,可通过胃癌淋巴转移的方法判断结直肠癌的预后及其外在因素。

摘要

Diaromatic esters. …??The esters correspond to the formula: …IMAGE… in which : R1 denotes H, OH, -CH3, -CH2OH, -CH(OH)CH3, -COOR9, …IMAGE… or SO2R10, R9 denotes H, C1-C6 alkyl or a mono- or polyhydroxyalkyl radical, R10 denoting OH, C1-C6 or …IMAGE… r' and r" denoting H, C1-C6 alkyl, aryl, aralkyl, mono- or polyhydroxyalkyl, or r' and r" taken together form a heterocyclic ring, R2 denoting H, C1-C6 alkyl, OR9, F or -CF3, R3, R4 and R5 denote H, F, OH, -CH3, -OCH3, -CF3, -COOH or -CH2OH, R6 and R8 denote H, alpha -substituted C3-C15 alkyl, alpha , alpha '-disubstituted C4-C12 alkyl, C3-C12 cycloalkyl, mono- or polycyclic C5-C12 cycloalkyl in which the connecting carbon is trisubstituted, -SR11, -SO2R11 or -SOR11, R11 denoting C1-C6 alkyl or cycloalkyl, R6 and R8 being unable to denote simultaneously H, R7 denotes H, C1-C6 alkyl, alkenyl, alkenyloxy, OR12 or SR13, R12 denoting H, C1-C6 alkyl or alkenyl, R13 denoting H, C1-C6 alkyl or aralkyl, provided that when R1 denotes -CH2OH, -CH(OH)CH3, -COOR9 or …IMAGE… and R2 denotes H then: (i) either R3 and R4 are other than H or -CH3, (ii) or R7 is other than the radical OR12 and R6 or R8 is cycloalkyl  C7, (iii) or R7 denotes OR12, but R6 and R8 are then other than H, (iv) or R7 denotes OR12, but then R5 is other than H. …??Use in human and veterinary medicine and in cosmetics.
机译:唾液酸酯。 …酯对应于下式:… ...其中:R1代表H,OH,-CH3,-CH2OH,-CH(OH)CH3,-COOR9,... ...或SO2R10, R 9表示H,C 1 -C 6烷基或单或多羟基烷基基团,R 10表示OH,C 1 -C 6或……r',而r”表示H,C 1 -C 6烷基,芳基,芳烷基,单或多羟基烷基,或r'和r“一起形成杂环,R2表示H,C1-C6烷基,OR9,F或-CF3,R3,R4和R5表示H,F,OH,-CH3,-OCH3,-CF3 ,-COOH或-CH 2 OH,R 6和R 8表示H,α-取代的C 3 -C 15烷基,α,α'-二取代的C 4 -C 12烷基,C 3 -C 12环烷基,单或多环C 5 -C 12环烷基,其中连接碳是三取代的-SR11,-SO2R11或-SOR11,R11表示C1-C6烷基或环烷基,R6和R8不能同时表示H,R7表示H,C1-C6烷基,烯基,烯基氧基,OR12或SR13,R12表示H,C 1 -C 6烷基或烯基,R 13表示H,C 1 -C 6烷基或芳烷基,条件是当R 1表示-CH 2 OH,-CH(OH)CH 3,-COO时R9或... ...并且R2表示H然后:(i)R3和R4不是H或-CH3,(ii)或R7不是基团OR12并且R6或R8是环烷基> C7,(iii )或R7表示OR12,但是R6和R8则不是H,(iv)或R7表示OR12,但是R5则不是H。…………用于人和兽药以及化妆品中。

著录项

  • 公开/公告号NO903183L

    专利类型

  • 公开/公告日1991-01-21

    原文格式PDF

  • 申请/专利权人 CIRD GALDERMA;

    申请/专利号NO19900003183

  • 发明设计人 SHROOT BRAHAM;BERNARDON JEAN-MICHEL;

    申请日1990-07-17

  • 分类号C07C69/773;

  • 国家 NO

  • 入库时间 2022-08-22 05:58:00

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