首页> 外国专利> DNA-SEQUENCES ENCODING MODIFIED EGLINS,VECTORS CONTAINING SUCH DNA SEQUENCES,HOSTS TRANSFORMED BY THE VECTORS,MODIFIED EGLIN POLYPEPTIDES PRODUCED BY THE TRANSFORMED HOSTS,METHODS FOR THE PREPARATION OF THE DNA SEQUENCES,VECTORS AND TRANSFORMED HOSTS,PROCESSES FOR THE PREPARATION OF MODIFIED EGLINS UTILIZING THE TRANSFORMED HOSTS AND PHARMACEUTICAL PRODUCTS CONTAINING THE MODIFIED EGLINS

DNA-SEQUENCES ENCODING MODIFIED EGLINS,VECTORS CONTAINING SUCH DNA SEQUENCES,HOSTS TRANSFORMED BY THE VECTORS,MODIFIED EGLIN POLYPEPTIDES PRODUCED BY THE TRANSFORMED HOSTS,METHODS FOR THE PREPARATION OF THE DNA SEQUENCES,VECTORS AND TRANSFORMED HOSTS,PROCESSES FOR THE PREPARATION OF MODIFIED EGLINS UTILIZING THE TRANSFORMED HOSTS AND PHARMACEUTICAL PRODUCTS CONTAINING THE MODIFIED EGLINS

机译：包含修饰的蛋白质的DNA序列，包含此类DNA序列的载体，由载体转化的宿主，由转化的宿主产生的修饰的多肽多肽，制备DNA序列的方法，载体，多肽和制备的多肽包含修饰过的蛋白质的转化后的宿主和药物产品

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1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE An eglin compound of the formula VGluPheGlySerGluLeuLysSerPhePro GluValValGlyLysThrValAspGlnAlaArgGlu TyrPheThrLeuHisTyrProGlnTyrAspVal WPheLeuProGluGlySerProValThrLeuAsp LeuArgTyrAsnArgValArgValPheTyr AsnProGlyThrAsnValValAsnHisValProHis ValGly in which V is N-acetyl-Thr and W is Tyr or His, and a pharmaceutically acceptable salt thereof. 1. Claims for the Contracting State : AT A process for the preparation of N**alpha -acetyl-eglin B, N**alpha -acetyl-eglin C and a salt thereof which comprises culturing an Escherichia coli or Saccharomyces cerevisiae strain which has been transformed with a DNA vector containing a DNA sequence coded for eglin B or eglin C and suitable for expression in E. coli or S. cerevisiae, in a liquid nutrient medium containing assimilatable sources of carbon and nitrogen, releasing the product from the host cells and isolating it, and, if desired, converting a resulting salt into the free polypeptide and converting a resulting polypeptide into a salt thereof.

机译：11.根据权利要求的缔约国：BE，CH，DE，FR，GB，IT，LI，LU，NL，式VGluPheGlySerGluLeuLysSerPhePro GluValValGlyLysThrValAspGlnAlaArgGlu TyrPheThrLeuHisTyrProGlnTyrAspVal WPheLeuProGluGlySerProValThrLeuAsp LeuArgTyrAsnArgValArgValPheTyr AsnProGlyThrAsnValValAsnHisValProHis ValGly的SE的水蛭抑制剂化合物，其中V是N-乙酰基Thr和W是Tyr或His，及其药学上可接受的盐。 1.缔约国的权利要求：A.一种制备N **α-乙酰基-eglin B，N **α-乙酰基-eglin C及其盐的方法，该方法包括培养具有以下特征的大肠杆菌或酿酒酵母菌株：在含有可模拟碳和氮源的液体营养培养基中，用含有编码例如eglin B或eglin C且适合在大肠杆菌或酿酒酵母中表达的DNA序列的DNA载体转化DNA，从宿主细胞中释放产物分离它，并且如果需要，将所得的盐转化为游离多肽，并将所得的多肽转化为其盐。

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公开/公告号IL73569A

专利类型
公开/公告日1991-05-12

原文格式PDF
申请/专利权人 CIBA-GEIGY AG;
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申请/专利号IL19840073569
发明设计人
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申请日1984-11-20
分类号C12N1/19;C12N1/21;C12N5/10;C12N15/15;C12N15/63;C12P21/02;C07K7/10;A61K37/64;
国家 IL
入库时间 2022-08-22 05:58:22

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