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BIO ADHESIVE EXTRUDED FILMS FOR INTRA-ORAL DRUG DELIVERY AND PROCESS FOR THEIR PREPARATION
BIO ADHESIVE EXTRUDED FILMS FOR INTRA-ORAL DRUG DELIVERY AND PROCESS FOR THEIR PREPARATION
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机译：用于口腔内药物递送的生物粘合剂挤出膜及其制备方法
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摘要
A bioadhesive extruded single or multi-layered thin film, especially useful in intra-oral controlled-releasing delivery, having a water soluble or swellable polymer matrix bioadhesive layer which can adhere to a wet mucous surface and which bioadhesive layer consists essentially of 40-95% by weight of a hydroxypropyl cellulose, 5-60% of a homopolymer of ethylene oxide, 0-10% of a water-insoluble polymer such as ethyl cellulose, propyl cellulose, polyethylene and polypropylene, and 2-10% of a plasticizer, said film having incorporated therein a medicament, e.g., anesthetics, analgesics, anticaries agents, anti-inflammatories, antihistamines, antibiotics, antibacterials, fungistats, etc.
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