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PERFUSATE FOR HEART

机译:为心脏着想

摘要

PURPOSE:To obtain a perfusate for heart containing a perfluorocarbon compound as an active ingredient and capable of supplying oxygen to cardiac muscle without causing degeneration, necrosis, etc., of cardiac muscle, especially in a form of emulsion. CONSTITUTION:A perfluorocarbon compound (e.g. perfluorodecalin) having oxygen carrying function and low in harmful reaction to living things or proper mixture thereof is emulsified each using a high macromolecular nonionic surfactant and/or phospholipid as an emulsifier and a fatty acid compound as an emulsifying auxiliary to give an emulsion, which is then isonically prepared by a physiological aqueous solution to provide the aimed product. The above- mentioned emulsion has preferably a composition consisting of 10-50w/v% perfluorocarbon compound, 2-5w/v% emulsifier and 0.004-0.1w/v% emulsifying auxiliary. The dose is 100-200ml/adult once, when the perfluorocarbon compound is contained in the emulsion at an amount of 10-50w/v%.
机译:目的:获得含有全氟化碳化合物作为活性成分的心脏灌流液,该灌流液能够向心肌供氧而不会引起心肌的变性,坏死等,尤其是以乳剂的形式。组成:具有高氧传递功能且对生物有害的反应低的全氟化碳化合物(例如全氟萘烷)或其适当的混合物,均使用高分子量非离子表面活性剂和/或磷脂作为乳化剂,并使用脂肪酸化合物作为乳化助剂进行乳化得到乳液,然后通过生理水溶液等距制备以提供目标产物。上述乳液优选具有由10-50w / v%的全氟化碳化合物,2-5w / v%的乳化剂和0.004-0.1w / v%的乳化助剂组成的组成。当乳液中全氟化碳化合物的含量为10-50w / v%时,剂量为100-200ml /成人一次。

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