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process for preparing derivatives of n7 - ammidin - replaced the mitomycin c.
process for preparing derivatives of n7 - ammidin - replaced the mitomycin c.
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机译:制备n7衍生物-mid胺-的方法代替了丝裂霉素c。
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摘要
There is disclosed a process for the preparation of N7-amidino substituted mitomycin C derivatives. The process comprises reacting mitomycin C or an N1a substituted derivative thereof such as porfiromycin with a chloroformimidinium salt in a polar solvent at low temperature. This reaction is conducted in the presence of a tertiary amine. This process eliminates the need for a strong base such as NaH prior to addition of a chloroformimidinium salt.
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