首页> 外国专利> The novel compounds comprising a sequence of oligonucleotide bound to an intercalating agent and has a chemical group can be activated, their synthesis and applications thereof by way of specific sequences of artificial nucleases. National scientific research centre (cnrs)

The novel compounds comprising a sequence of oligonucleotide bound to an intercalating agent and has a chemical group can be activated, their synthesis and applications thereof by way of specific sequences of artificial nucleases. National scientific research centre (cnrs)

机译：包含与插入剂结合的寡核苷酸序列并具有化学基团的新型化合物可以通过人工核酸酶的特定序列被活化，其合成和应用。国家科研中心（CNRS）

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摘要

Chemical compounds consisting of an oligonucleotide or an oligodeoxynucleotide comprising a chain sequence of natural or modified nucleotides and bonded by a covalent bond to an insertion radical and to a reactive chemical radical. These compounds can be employed as artificial nucleases specific for nucleic acid sequences. They can be employed for selective blocking of the expression of a gene chosen beforehand by acting directly either on the genetic data or on the messenger RANs.

机译：由寡核苷酸或寡脱氧核苷酸组成的化合物，其包含天然或修饰核苷酸的链序列，并通过共价键与插入基团和反应性化学基团键合。这些化合物可用作核酸序列特异的人工核酸酶。通过直接作用于遗传数据或信使RAN，它们可用于选择性阻断预先选择的基因的表达。

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公开/公告号FR2586704B1

专利类型
公开/公告日1987-12-18

原文格式PDF
申请/专利权人 CENTRE NAL RECHERC SCIENTIFIQUE;
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申请/专利号FR19850013132
发明设计人 NGUYEN THANH THUONG ET CLAUDE HELENE;HELENE CLAUDE;
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申请日1985-09-04
分类号C12Q1/68;A61K31/70;C07H21/02;C07H21/04;C12N15/00;
国家 FR
入库时间 2022-08-22 06:51:16

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