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ANTIMICROBIAL COMPOSITIONS CONTAINING 1-ETHYL-6- FLUORO-1,4-DIHYDRO-4-OXO-7-(1-PIPERAZINYL)-3- QUINOLINE CARBOXYLIC ACID OR METAL SALTS THEREOF AND SILVER SULFADIAZINE
ANTIMICROBIAL COMPOSITIONS CONTAINING 1-ETHYL-6- FLUORO-1,4-DIHYDRO-4-OXO-7-(1-PIPERAZINYL)-3- QUINOLINE CARBOXYLIC ACID OR METAL SALTS THEREOF AND SILVER SULFADIAZINE
ANTIMICROBIAL COMPOSITIONS CONTAINING1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-7-(1-PIPERAZINYL)-3-QUINOLINE CARBOXYLIC ACIDOR METAL SALTS THEREOF AND SILVER SULFADIAZINEABSTRACT OF THE DISCLOSURECompositions which include 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid or itsmetal salts, e.g., silver, zinc, cobalt or cerium salts, andsilver sulfadiazine are effective in the treatment of burns.Of special interest are compositions containing silver sulfa-diazine and the silver salt of the above-identified quino-line carboxylic acid, wherein even though each compound ispresent in a concentration which would be ineffective ifeither compound were present alone, the resulting composi-tions are effective. The compositions of this inventionmay be applied to the affected surface of a burn victimeither directly or in combination with a physiologically ac-ceptable carrier, such as a water-dispersible, hydrophiliccarrier.
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