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55FLUOROO66HYDROXYY66CARBOXYY5*66DIHYDROOURACIL AND ITS PREPARATION
55FLUOROO66HYDROXYY66CARBOXYY5*66DIHYDROOURACIL AND ITS PREPARATION
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机译：55FLUOROO66HYDROXYY66CARBOXYY5 * 66双氢尿酸及其制备方法
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摘要
NEW MATERIAL:5-FLUORO-6-hydroxy-6-carboxy-5,6-dihydrouracil expressed by the formula. USE:An intermediate for a fluorine-containing compound, e.g.5-fluorouracil, etc., useful as an anti-tumor agent. PREPARATION:A desired compound is prepared by reacting orotic acid with fluorine gas in the presence of water. Preferably the reaction is carried out in formic acid containing 5-20 wt.% of water as a solvent at 5-50 deg.C. Orotic acid-hydrate is advantageously used as the acid source due to its high availability, etc., and fluorine gas is preferably diluted with an inert gas. Fluorine gas may be replaced by trifluoromethylhypofluorite. The desired compound can be easily separated from the unreacted materials with water, and thermal treatment of the aqueous solution at = 130 deg.C easily gives 5-fluorouracil.
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