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agent for intensifying the anticancer action of an anticancer agent.

机译:用于增强抗癌剂的抗癌作用的药剂。

摘要

An agent for enhancing antitumor activity of antitumor agents comprising as the active ingredient diltiazem or a pharmaceutically acceptable acid addition salt thereof, an antitumor composition comprising the diltiazem or an acid addition salt thereof and a conventional antitumor agent, and further a method for treating tumors by administering diltiazem or an acid addition salt thereof together with a conventional antitumor agent in oral or parenteral route to patients suffering from various tumors. Said active diltiazem or a salt thereof is effective for enhancing the antitumor activity of antitumor agents because it can enhance sensitivity of tumor cells to antitumor agents regardless the tumor cells have resistance to the antitumor agents or not.
机译:用于增强抗肿瘤剂抗肿瘤活性的药物,包括地尔硫卓或其药学上可接受的酸加成盐作为活性成分,包含地尔硫卓或其酸加成盐和常规抗肿瘤剂的抗肿瘤组合物,以及进一步的用于通过以下方法治疗肿瘤的方法:以口服或肠胃外途径将地尔硫卓或其酸加成盐与常规抗肿瘤剂一起给予患有各种肿瘤的患者。所述活性地尔硫卓或其盐可有效增强抗肿瘤剂的抗肿瘤活性,因为其可增强肿瘤细胞对抗肿瘤剂的敏感性,而不管肿瘤细胞是否对抗肿瘤剂具有抗性。

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