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PROSTACYCLIN ANALOGUES AND THEIR USE IN INHIBITION OF ARACHIDONIC ACID-INDUCED PLATELET AGGREGATION AND BRONCHOCONSTRICTION
PROSTACYCLIN ANALOGUES AND THEIR USE IN INHIBITION OF ARACHIDONIC ACID-INDUCED PLATELET AGGREGATION AND BRONCHOCONSTRICTION
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机译:前列腺素类似物及其在抑制花生四烯酸诱导的血小板凝集和支气管扩张中的用途
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摘要
Prostacyclin analogs are provided having the structure IMAGE wherein X represents =O or OH, R1 and R2 are OH or H, provided at least one of R1 and R2 is other than hydroxyl, R3 is H or alkyl of 1 to 4 carbons, m is an integer of from 2 to 5, and n is an integer of from 2 to 10, or pharmaceutically acceptable salts thereof. These compounds have been found to be potent inhibitors of arachidonic acid-induced platelet aggregation and bronchoconstriction.
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