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seen framstella new 4 '- or 5' - substituted thiazole - 2 '- oximetylenoxazolidinderivat
seen framstella new 4 '- or 5' - substituted thiazole - 2 '- oximetylenoxazolidinderivat
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机译：见新出现的弗雷斯特氏菌4'-或5'-取代的噻唑-2'-肟基苯并恶唑烷
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摘要
1-Amino-3-(4- or 5-substituted thiazol-2-oxy)-2-propanol and/or substituted amino derivatives thereof: 3-(4-or 5-substituted thiazon-2-oxy)-1,2-epoxypropane and 5-(4-or 5-substituted thiazol-2-oxy)-1,2-epoxypropane and 5-(4-or 5-substituted thiazol-2-oxymethylene)-oxazolidine and/or N- and/or -substituted oxazolidine derivatives thereof, generally represented by comound formulas: (I) (II) (III) wherein R1, R2, R5, R6, R7 and Z are the various substituents and methods of making such compounds. The compounds are characterized by an aminocarbonyl or carbonylamino type substituent at the 5- or 4-position on the thiazole ring. The above 1-amino-3-(4- or 5-substituted thiazol-2-oxy)-2-propanol and derivatives exhibit cardiovascular activity and are useful in the treatment of abnormal heart conditions in mammals. The 3-(4- or 5-substituted thiazol-2-oxy)-1,2-epoxypropanes are useful as intermediates for the aforementioned cardiovascular agents. The 5-(4- or 5-substituted thiazol2-oxymethylene)-oxazolidine and derivatives are intermediates for the aforementioned cardiovascular agents and further exhibit cardiovascular activity and thus are useful in the treatment of abnormal heart conditions in mammals. The 1amino-3-(4- or 5-substituted thiazol-2-oxy)-2-propanol and derivatives can be prepared by base or acid hydrolysis of the corresponding 5-(4- or 5-aminocarbonylthiazol-2-oxymethylene)-oxazolidine or derivative; or by treatment of the corresponding 3-(4- or 5-substituted thiazol-2-oxy)-2, 3epoxypropane or derivative with the desired amine or amine derivative.
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