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A method for the isolation and separation of psoralen and isopsoralen
A method for the isolation and separation of psoralen and isopsoralen
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机译:补骨脂素和异补骨脂素的分离和分离方法
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摘要
Psoralone and isopsoralone, (furanocoumarins), are isolated from psoralea corylifolia seeds, which are ground, sieved, washed with water and extracted with toluene, benzene or CHCl3 under pressure; the extract is repeatedly washed with dilute NaOH, evapd. and mixed with a hydrocarbon solvent such as kerosine or petroleum ether, when psoralone crystallises; the mother liquor is cooled to yield isopsoralone. The products are purified by treatment with active charcoal and recrystallised from methylated spirit. The related ammoidin is similarly obtained from ammi majus seeds. These cpds. are valuable for the treatment of psoriasis, leucodermatitis, leprosy and other skin complaints.
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