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A method for the isolation and separation of psoralen and isopsoralen

机译:补骨脂素和异补骨脂素的分离和分离方法

摘要

Psoralone and isopsoralone, (furanocoumarins), are isolated from psoralea corylifolia seeds, which are ground, sieved, washed with water and extracted with toluene, benzene or CHCl3 under pressure; the extract is repeatedly washed with dilute NaOH, evapd. and mixed with a hydrocarbon solvent such as kerosine or petroleum ether, when psoralone crystallises; the mother liquor is cooled to yield isopsoralone. The products are purified by treatment with active charcoal and recrystallised from methylated spirit. The related ammoidin is similarly obtained from ammi majus seeds. These cpds. are valuable for the treatment of psoriasis, leucodermatitis, leprosy and other skin complaints.
机译:从补骨脂种子中分离出补骨脂和异补骨脂(呋喃香豆素),将其研磨,过筛,用水洗涤,并在压力下用甲苯,苯或CHCl3萃取;萃取液用稀NaOH重复洗涤,蒸发。当普索拉诺结晶时,与烃溶剂如煤油或石油醚混合;将母液冷却以产生异op索龙。通过用活性炭处理来纯化产物,并从甲基化酒精中重结晶。类似地,相关的氨蝶呤获自ammi majus种子。这些cpds。在治疗牛皮癣,白带病,麻风病和其他皮肤不适方面很有价值。

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