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method for the preparation of n-substituted aminoalkylethers of alkoxybenzeenderivaten pharmacological effect method for the preparation of compounds with pharmacological activity.and formed preparations obtained under application of the latter method.
method for the preparation of n-substituted aminoalkylethers of alkoxybenzeenderivaten pharmacological effect method for the preparation of compounds with pharmacological activity.and formed preparations obtained under application of the latter method.
1,251,695. Aminoalkyl ethers of 2-(alkoxy) - 3,5-dihalobenzenes. SOC. D'ETUDES SCIENTIFIQUES ET INDUSTRIELLES DE L'ILE-DE-FRANCE. 13 Feb., 1969 [16 Feb., 1968; 10 May, 1968], No. 7933/69. HeadingC2C. Novel compounds of the Formula (I) and their acid-addition salts with a mineral or organic acid and their quaternary ammonium salts, wherein n and m each is 0, 1 or 2, R, R l and R 2 each is H or C 1-5 alkyl, R 3 is C 1-5 alkyl, or the group NR 1 R 2 represents a heterocyclic radical, and X and Y are halogens, are obtained by acetylating a monoether of pyrocatechol, then halogenating the product, de-acetylating the halogenated product and treating the dihalo-pyrocatechol monoether with an appropriate (substituted amino) alkyl chloride, and optionally forming acid or quaternary ammonium salts. Pharmaceutical compositions, useful as spasmogenie agents, contain compounds of Formula (I) above as active ingredients, and may be formulated as tablets or solutions.
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