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TEMPERATURE-SENSITIVE HYDROGEL COMPOSITION FOR PREVENTING TISSUE ADHESION, AND PREPARATION METHOD THEREFOR
TEMPERATURE-SENSITIVE HYDROGEL COMPOSITION FOR PREVENTING TISSUE ADHESION, AND PREPARATION METHOD THEREFOR
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机译：用于防止组织粘附的温度敏感水凝胶组合物，以及其制备方法
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摘要
The present invention relates to a hydrogel composition for preventing tissue adhesion, and a preparation method therefor, and the hydrogel composition is composed of a polyethylene oxide-polypropylene oxide-polyethylene oxide terpolymer, a water-insoluble hyaluronic acid, sodium alginate and purified water and is prepared through the preparation method comprising: a copolymer melting step of heating, for one to two hours at a temperature of 60-100°C, a polyethylene oxide-polypropylene oxide-polyethylene oxide terpolymer having a molecular weight of 1-500 kDa, and melting same; a hyaluronic acid mixing step of mixing a molten product, having been prepared through the copolymer melting step, with a water-insoluble hyaluronic acid and stirring same at a temperature of 10-20°C; and a sodium alginate mixing step of mixing a mixture, having been prepared through the hyaluronic acid mixing step, with sodium alginate and stirring same at a temperature of 5-20°C. In a hydrogel composition for preventing tissue adhesion, which is composed of the ingredients and is prepared by the preparation method, and a preparation method therefor, a polyethylene oxide-polypropylene oxide-polyethylene oxide terpolymer having the capacity to suppress tissue adhesion is used as a basic structure, and a water-insoluble hyaluronic acid and sodium alginate are blended, and thus a hydrogel composition for preventing tissue adhesion, to be uniformly coated on an in vivo wound site, is provided.
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