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METHOD OF CREATING CHARACTERISTIC PROFILES OF MASS SPECTRA AND IDENTIFICATION MODEL FOR ANALYZING AND IDENTIFYING FEATURES OF MICROORGANIZMS
METHOD OF CREATING CHARACTERISTIC PROFILES OF MASS SPECTRA AND IDENTIFICATION MODEL FOR ANALYZING AND IDENTIFYING FEATURES OF MICROORGANIZMS
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机译:创造质谱与识别模型的特征谱的方法分析和识别微生物的特征
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摘要
A method of creating characteristic profiles of mass spectra and identification model for analyzing and identifying microorganisms includes obtaining data of MALDI-TOF MS of microorganisms having same features; using a kernel density estimation to generate characteristic profiles of an m/z of the data; creating a characteristic MS profile based on the m/z; repeating above three step until characteristic MS profiles of features of the microorganisms is obtained; comparing m/z of MALDITOF MS spectrum of known microorganisms with the characteristic profiles to obtain first matched vectors; using a machine learning method to establish a feature classification model; using MALDI-TOF MS to analyze microorganisms having unknown features; comparing the m/z of MALDI-TOF MS spectrum of the microorganisms having unknown features with the characteristic MS profiles to obtain second matched vectors; using the feature classification model to analyze the second matched vectors; and identifying the microorganisms having the unknown features.
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