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Dementia animal model comprising dementia risk factors characterized by male-specific dementia predicting markers and its manufacturing method
Dementia animal model comprising dementia risk factors characterized by male-specific dementia predicting markers and its manufacturing method
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机译：痴呆动物模型，包括痴呆患者，其特征是由男性特异性痴呆预测标志物及其制造方法的特征
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摘要
The present invention relates to a dementia animal model and a method of manufacturing the same, including a complex dementia risk factor characterized by a male-specific dementia predictive index, and more specifically, to a simple physiologically dementia without high-difficulty techniques such as transformation. It can be induced, and its phenotype includes a combination of risk factors for dementia, which are manifested by increased acetylcholinesterase activity in male-specific hippocampal tissue, increased systolic blood pressure, increased blood sugar, decreased vascular endothelial-dependent relaxation rate of the carotid artery, and decreased high-density lipoprotein in the blood. It relates to an animal model of dementia. The animal model of dementia according to the present invention reflects the major risk factors of dementia, such as high blood sugar and high blood pressure, and has the advantage of being cost-effective because the manufacturing method is simple compared to the existing animal model of dementia, and the phenotype is male-specific hippocampus. It is useful to study the mechanism of sex-specific dementia or to develop drugs for the prevention and treatment of sex-specific dementia by increasing tissue acetylcholinesterase activity, increasing systolic blood pressure, increasing blood sugar, reducing the vascular endothelial-dependent relaxation rate of the carotid artery, and decreasing high-density lipoproteins in the blood.
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