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首页> 外国专利> METHOD FOR STUDYING EFFECT OF SECRETOME COMPONENT - GRANULIN OPISTHORCHIS FELINEUS ON FORMATION OF NEW ISLETS OF THE PANCREAS

METHOD FOR STUDYING EFFECT OF SECRETOME COMPONENT - GRANULIN OPISTHORCHIS FELINEUS ON FORMATION OF NEW ISLETS OF THE PANCREAS

机译：沉粒组分 - 粒素Opisthorchis Feliness对胰腺新胰岛形成的影响的研究

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FIELD: medicine.;SUBSTANCE: invention relates to medicine, in particular to cell biology, cytology and histology. To study the effect of the secretome component, Opisthorchis felineus granulin, on the formation of new islets of the pancreas, samples of pancreatic tissue are taken from persons who have suffered from superinvasive opisthorchiasis in their lifetime, in which the obtained samples are fixed in formalin, embedded in paraffin, and sections are made. The obtained sections are stained with hematoxylin and eosin, an immunohistochemical study is performed, the index of cell proliferative activity is calculated, and the quantitative parameters of the islets of the pancreas are assessed. Total number of islets over 20 microns in diameter is determined, and of these, the number of large islands over 200 microns in diameter. The islet endocrinocyte index (ECI) is calculated. When identifying islets with an area of ​​604.84-697.18 microns2, with a chaotic arrangement, crowding up to 1.4-3.05 in 1 field of view, with ECI - 0.31-0.35, with the absence or formation of a capsule, it is determined newly formed islets of Langerhans.;EFFECT: allows to identify newly formed islets of Langerhans, formed as a result of the action of the secretome component - granulin Opisthorchis felineus.;1 cl, 9 dwg
机译：田地：药物。物质：发明涉及药物，特别是细胞生物学，细胞学和组织学。为了研究秘密组分的影响，Opisthorchis Felineus粒细胞对胰腺的新胰岛的形成，胰腺组织的样品取自患者的寿命，其中所获得的样品在福尔马林中固定，嵌入石蜡中，并进行切片。将得到的部分用苏木精化和曙红染色，进行免疫组化研究，计算细胞增殖活性的指数，并评估胰腺的胰岛的定量参数。直径超过20微米的胰岛总数，其中大于直径200微米的大岛的数量。计算胰岛内分泌细胞指数（ECI）。当识别面积604.84-697.18微米的胰岛 2 时，在混乱的安排中，在1个视野中挤出高达1.4-3.05，ECI - 0.31-0.35，缺席或形成胶囊，它是确定的新形成朗格汉斯的胰岛。;效果：允许鉴定植物植物的新形成的胰岛，由沉粒组分 - 粒状Opisthorchis Felecedus的作用形成。; 1 cl，9 dwg

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