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antigen binding molecule capable of binding to CD3 and CD137 but not simultaneously

机译:抗原结合分子能够结合CD3和CD137但不同时结合

摘要

The present invention provides an antigen-binding molecule that binds to CD3 and CD137 (4-1BB); a composition comprising the antigen-binding molecule of interest; and how to use it. The present invention provides an antibody variable region capable of binding CD3 and CD137 (4-1BB) but not simultaneously binding CD3 and CD137, and a variable region that binds to a third antigen different from CD3 and CD137, Antigen-binding molecules are provided. Such antigen binding molecules exhibit enhanced T cell dependent cytotoxic activity induced by these antigen binding molecules through binding to three different antigens.
机译:本发明提供了一种与CD3和CD137(4-1Bb)结合的抗原结合分子;一种包含感兴趣的抗原结合分子的组合物;以及如何使用它。本发明提供了一种能够结合CD3和CD137(4-1Bb)但不同时结合CD3和CD137的抗体可变区,并提供与与CD3和CD137不同的第三抗原,抗原结合分子结合的可变区。这种抗原结合分子通过结合三种不同的抗原表现出由这些抗原结合分子诱导的增强的T细胞依赖性细胞毒性活性。

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