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Heterodimers of IL-15 and IL-15R alpha to increase thymic output and to treat lymphopenia

机译：IL-15和IL-15Rα的异二聚体增加胸腺输出并治疗淋巴细胞症

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摘要

The present invention provides method for promoting the maturation and export of T cells from thymic tissue by contacting the thymic tissue with supraphysiological levels of interleukin (IL)-15. The present invention also provides methods for preventing, alleviating, reducing, and/or inhibiting lymphopenia or peripheral depletion of lymphocytes in a patient in need thereof by administering to the patient IL-15.

机译：本发明提供了通过使胸腺组织与白细胞介素（IL）-15的高级水平接触来促进来自胸腺组织的T细胞的成熟和出口T细胞的方法。本发明还提供了通过向患者IL-15给予需要预防，减轻，减少和/或抑制淋巴细胞或淋巴细胞的淋巴细胞或外周耗尽的方法。

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公开/公告号US11041008B2

专利类型
公开/公告日2021-06-22

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申请/专利权人 THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES;
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申请/专利号US201816123431
发明设计人 CRISTINA BERGAMASCHI;BARBARA K. FELBER;GEORGE N. PAVLAKIS;ANTONIO VALENTIN;
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申请日2018-09-06
分类号C07K14/54;C07K14/715;C12N15/62;C12P19/30;C12N5/16;A61K38/17;A61K45/06;A61K48;A61K47/68;A61K38/20;C12N15/09;A61K38/14;A61K38;C12N5/07;C12N15/113;C12P21/02;
国家 US
入库时间 2022-08-24 19:29:00

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