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首页> 外国专利> METHOD FOR INCREASING THE EFFICIENCY OF INTENSIVE THERAPY IN SEVERE-BURNED AND EXTREMELY SEVERE-BURNED

METHOD FOR INCREASING THE EFFICIENCY OF INTENSIVE THERAPY IN SEVERE-BURNED AND EXTREMELY SEVERE-BURNED

机译：提高严重烧伤和极其严重烧伤的强化治疗效率的方法

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FIELD: medicine. ;SUBSTANCE: invention relates to medicine, namely to efferent therapy, combustiology, anesthesiology and resuscitation, and can be used to increase the effectiveness of intensive therapy for severely burned and extremely severely burned. To do this, against the background of combined extracorporeal detoxification in the first period of burn disease in the presence of the following symptoms: persistent hypotension with a decrease in mean arterial pressure to less than 65 mm Hg. against the background of adequate infusion therapy and an increase in the level of endotoxin activity of ≥0.6 or the identification of gram-negative flora according to the bacteriological study of biological media, selective adsorption of lipopolysaccharide is carried out or prolonged hemodiafiltration is used in the first period in the presence of one or the following indications: acute kidney damage of stage 2 or acute kidney damage of stage 1 in the presence of acute respiratory distress syndrome or clinical and laboratory signs of shock, or in the first period of burn disease in the presence of liver failure in the patient with SOFA score 2-4 points "liver" without a tendency to regress against the background of intensive conservative the therapy is carried out by selective plasma filtration; in the second and third periods of burn disease, measures are taken for the first period, but instead of prolonged hemodiafiltration, prolonged hemodiafiltration is used, while in the presence of severe hypernatremia, which is more than 155 mmol/l, not amenable to conservative correction, renal replacement therapy is performed; In all periods of burn disease in severely burned and extremely severely burned patients with signs of burn or septic shock, the above measures of the algorithm are supplemented with selective sorption of cytokines until blood pressure stabilizes.;EFFECT: method makes it possible to avoid the development of an unfavorable outcome in the most dangerous periods of burn disease due to the early differentiated use of methods of extracorporeal detoxification as part of intensive therapy, taking into account the staged course of the burn disease and the severity of organ dysfunctions.;1 cl, 1 ex
机译：领域：医学。物质：本发明涉及医学，即传出治疗，燃烧生殖，麻醉学和复苏，并且可用于增加强烈灼伤和极其严重烧伤的强化疗法的有效性。为此，在烧伤疾病的第一个症状中，在烧伤疾病的第一个症状中的结合后体外解毒背景：持续的低血压，其平均动脉压低降低至小于65mm Hg。在适当输注治疗的背景下，内毒素活性水平≥0.6或根据生物介质的细菌学研究鉴定革兰氏阴性菌群，进行脂多糖的选择性吸附或延长的血液过滤器在存在一个或以下适应症的第一个时期：急性肾脏损伤的阶段2或急性肾脏损伤的阶段1在存在急性呼吸窘迫综合征或临床和实验室的休克症状，或在烧伤疾病的第一期患者在患者中存在肝脏衰竭2-4点“肝脏”而不会倾向于在密集保守的背景下回归治疗，通过选择性等离子体过滤进行;在烧伤疾病的第二个和第三期，采取措施的第一期，但使用延长的血液透析而不是长时间的血液过滤，而在存在严重的高血脂血症的情况下，这是超过155mmol / L，而不是保守的校正，进行肾置换疗法;在所有烧伤疾病中，严重灼伤和极其严重燃烧的灼伤症患者的烧伤或脓毒症休克的患者，算法的上述措施都补充了细胞因子的选择性吸附，直至血压稳定。;效果：方法可以避免由于早期分化使用体外解毒方法，作为密集疗法的一部分，在烧伤疾病中产生不利结果的发展，同时考虑到烧伤疾病的分阶段和器官功能障碍的严重程度。; 1 CL ，1前

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