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Synthetic cannabinoid compounds for treatment of substance addiction and other disorders

机译：用于治疗物质成瘾和其他疾病的合成大麻化合物

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摘要

A method of increasing the cannabinoid levels in a genetically modified Cannabis sativa plant includes genetically modifying the plant to induce the overexpression of the gene that controls the expression of tetrahydrocannabinolic acid (THCA) synthase and/or cannabidiolic acid (CBDA) synthase. The overexpression of THCA synthase and CBDA synthase catalyzes an increased synthesis of cannabigerolic acid to tetrahydrocannabinolic acid and cannabidiolic acid, as well as the cannabinoids (3aR)-2,4,4-trimethyl-7-pentyl-3,3a,4,9b-tetrahydrocyclopenta[c]chromen-9-ol and 2-((1R,5R)-3-methyl-5-(prop-1-en-2-yl)cyclopent-2-en-1-yl)-5-pentylbenzene-1,3-diol. Pharmaceutical compositions comprising the modified cannabinoids produced by the transgenic Cannabis sativa plant or prepared synthetically are used to treat various diseases and conditions.

机译：一种增加遗传修饰的大麻苜蓿植物中的大麻素水平的方法包括遗传修饰植物以诱导控制四氢甘油酸（THCA）合酶和/或大麻醇（Cancabidiolic acid）表达的基因的过表达（ CBDA）合成酶。 THCA合酶和CBDA合酶的过表达催化Cannabigerolic酸与四氢吲哚醇和大麻酸的合成增加，以及大麻素（3AR）-2,4,4-三甲基-7-戊基-3,3a，4,9b -teTrahydyclopenta [C] Chromen-9-Ol和2 - （（1R，5R）-3-甲基-5-（PROP-1-ZEN-2-Y1）圈 - 2-en-1-YL）-5- 戊苯-1,3-二醇。药物组合物包含由转基因大麻苜蓿植物制备的改性大麻素或合成制备的改性的大麻素用于治疗各种疾病和病症。

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公开/公告号US11085047B2

专利类型
公开/公告日2021-08-10

原文格式PDF
申请/专利权人 MYMD PHARMACEUTICALS (FLORIDA) INC.;
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申请/专利号US201916612472
发明设计人 JONNIE R. WILLIAMS;
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申请日2019-02-11
分类号C07C39/23;C07D311;A61K31;C12N15;C12N15/82;A61K31/352;A61K36/185;
国家 US
入库时间 2022-08-24 20:29:23

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