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IVACAFTOR GLYCOSIDES, METHODS OF MAKING, AND USES THEREOF IN TREATING CYSTIC FIBROSIS

机译:Ivacafacter糖苷,制备方法,以及其用途治疗囊性纤维化

摘要

Ivacaftor glycosides and methods of making ivacaftor glycosides are disclosed. Glycosyl transferases catalyze addition of one or more monosaccharides to ivacaftor to yield ivacaftor glycosides. Suitable monosaccharides can be in the L- or D- configuration and typically have 5, 6, or 7 carbons. Suitable monosaccharides include allose, apiose, arabinose, fructose, fucitol, fucose, galactose, glucose, glucuronic acid, mannose, A-acetylglucosamine, rhamnose, or xylose. Uridine diphosphate glycosyl transferases can catalyze formation of either an alpha or beta glycosidic bond.
机译:公开了Ivacafacter糖苷和制备Ivacafacter糖苷的方法。 糖基转移酶催化添加一种或多种单糖至Ivacafaceror以产生Ivacaftor糖苷。 合适的单糖可以在L-或D-构型中,并且通常具有5,6或7个碳。 合适的单糖包括雄糖,Apiose,阿拉伯糖,果糖,糖醇,岩藻糖,半乳糖,葡萄糖,葡糖醛酸,甘露糖,A-乙酰葡糖胺,鼻窦或木糖。 尿苷二磷酸糖基转移酶可以催化形成α或β糖苷键的形成。

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