首页> 外国专利> Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders

Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders

机译:治疗胆酸相关疾病的方法和对胆酸相关疾病治疗的临床敏感性预测

摘要

Provided herein are methods of using 7α-hydroxy-4-cholesten-3-one (C4) in predicting the clinical sensitivity to treatment of bile acid-related and associated disorders with treatment peptides, such as variants of fibroblast growth factor 19 (FGF19) proteins and peptide sequences (and peptidomimetics) and fusions of FGF19 and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), and variants of fusions of FGF19 and/or FGF21 proteins and peptide sequences (and peptidomimetics).
机译:本文提供了使用7α-羟基-4-胆固醇-3-一(C4)的方法,以预测与治疗肽的胆酸相关和相关疾病治疗的临床敏感性,例如成纤维细胞生长因子19的变体(FGF19) 蛋白质和肽序列(和肽模拟物)和FGF19和/或成纤维细胞生长因子21(FGF21)蛋白质和肽序列(以及肽模拟物)的融合,以及FGF19和/或FGF21蛋白和肽序列(以及肽瘤的肽的变异。

著录项

  • 公开/公告号US11141460B2

    专利类型

  • 公开/公告日2021-10-12

    原文格式PDF

  • 申请/专利权人 NGM BIOPHARMACEUTICALS INC.;

    申请/专利号US201916562150

  • 发明设计人 ALEXANDER MARK DEPAOLI;JIAN LUO;HUI TIAN;

    申请日2019-09-05

  • 分类号A61K38/18;G01N33/92;G01N33/68;A61P1;G01N33/50;

  • 国家 US

  • 入库时间 2022-08-24 21:37:20

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号