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多处损伤

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  • 陈莉
  • 李仲
  • 葛森
  • 郁大照
  • 张积广
  • 段成美
  • 刘国强
  • 刘秀丽
  • 徐晓飞
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    • 孙汉斌; 董登科; 陈莉; 常文魁
    • 摘要: 基于无预制裂纹3排平行孔平板的疲劳试验,对含相似应力水平的多细节结构产生多处损伤(Multiple Site Damage,MSD)的规律进行了研究。为了研究产生MSD结构中裂纹之间的干涉影响,利用Franc2D/L对主裂纹、等长双侧裂纹,等长单双裂纹、单孔等长双裂纹四种开裂模式的裂纹应力强度因子进行了计算分析。计算结果表明:裂纹扩展初期,裂纹主要受到自身开裂孔的干涉影响,四种模式下裂纹的无量纲应力强度因子比较相近;随着裂纹长度的增加,试验和有限元结果都表明了裂纹间的干涉影响显著加快了裂纹的扩展速度。
    • 赵树力; 余音; 徐武
    • 摘要: 为改进疲劳多裂纹扩展问题的分析,建立了常规态型近场动力学的疲劳多裂纹扩展模拟方法.在常规态型近场动力学的理论框架基础上,采用近场动力学疲劳裂纹萌生和扩展模型,建立了一个可模拟疲劳裂纹萌生与扩展的平面应力近场动力学模型.针对近场动力学疲劳模型计算量庞大的问题,又引入"临界断裂数"来优化模型的计算流程,提升模型的计算速度,以单边裂纹板为研究对象,通过选取不同"临界断裂数"的值寻求计算效率与裂纹路径精准度之间的平衡.从计算结果的对比中可以发现,当采用恰当的"临界断裂数"时,计算速度得到了较大的提升,同时裂纹仍能保证精准的形状.然后,该模型被用于非共线多裂纹板的疲劳破坏模拟仿真之中,当采用不同的"临界断裂数"时,计算运行得到的疲劳裂纹扩展路径以及相应的a-N曲线均能与实验得到的结果取得良好的吻合.研究结果表明,近场动力学疲劳分析方法不需引入断裂准则和预知裂纹路径,裂纹可以任意扩展.
    • 孙汉斌; 董登科; 陈莉; 常文魁
    • 摘要: 首先基于LY12CZ铝合金平板的中心裂纹扩展速率试验,考虑裂纹扩展速率的随机性,采用三参数对数正态分布表征Paris公式参数的分布特性,建立了LY12CZ随机裂纹扩展分析方法.利用Monte-Carlo法模拟裂纹扩展的随机性,进一步建立了多处损伤(multiple site damage,MSD)含孔结构随机裂纹扩展寿命预测模型,并将模型程序化.通过算例验证分析,该模型能够较准确预测多处损伤含孔结构裂纹扩展寿命,得到结构的失效概率,为含孔结构的MSD评估提供有效的工程分析方法.
    • 张腾; 何宇廷; 伍黎明; 左智元; 杜鑫
    • 摘要: 建立了含有广布损伤(MSD)裂纹的无干涉铆接搭接结构三维有限元模型,求解裂纹尖端左右两侧的应力强度因子,并提出了等效应力强度因子的概念.以Paris公式为基础,结合改进的载荷循环叠加方法、塑性区连通准则,并考虑MSD裂纹扩展中的相关性,建立了等幅谱下MSD裂纹扩展预测模型.计算结果与试验结果表明,使用该方法预测的3种开裂模式下的寿命值误差均在7%以内;对搭接结构进行分析不能简化为二维模型;MSD裂纹扩展寿命与结构开裂模式有关,结构中共存的裂纹越多其裂纹扩展寿命越短.
    • 李勇; 金兆辰; 蔡燕; 吉木森; 杨宏锋; 刘竞; 虞志新
    • 摘要: Objective To determine the influence of continuous mild sedation versus usual sedation on the sedative effect and inflammatory factor level in ICU patients with multiple trauma.Methods In this prospective, randomized double-blind investigation, 58 multiple trauma patients hospitalized from October 2013 to April 2015 were randomized into continuous mild sedation group (continuous group, n =30) and conventional sedation group (conventional group, n =28) using the sealed envelopes.Between-group differences were made on the duration of mechanical ventilation, length of stay in the ICU, ratio of inception of continuous renal replacement therapy (CRRT), tracheotomy rate, accidental extubation rate, sepsis rate, multiple organ failure (MOF) rate and mortality.Serum inflammatory factor levels of the patients were recorded.Results There were 3 deaths (10%) in continuous group versus 4 deaths (14%) in conventional group (P > 0.05).Patients in continuous group showed significantly less time spent on mechanical ventilation [(4.8 ±2.7) vs.(8.9 ±3.1)d] and in the ICU [(10.7 ± 5.4) vs.(16.9 ± 7.3) d] compared with conventional group (P < 0.01).Between-group differences were insignificant regarding the ratio of CRRT inception, tracheotomy rate, accidental extubation rate, sepsis rate and MOF rate (P > 0.05).Serum levels of interleukin (IL)-6, tumor necrosis factor (TNF)-α, Creactive protein (CRP) were lower in continuous group than those in conventional group at 24 h, 48 h and 72 h post-ICU, but significant differences were only observed at 48 h (P < 0.05).At these time periods, serum IL-10 levels in continuous group were significantly higher than those in conventional group (P <0.05).In receiver operative characteristic curve (ROC) analysis, the area under the curve for IL-6, IL-10, TNF-α and CRP in continuous group was 0.726, 0.608, 0.729 and 0.757 respectively at 48 h post-ICU, indicating a predictive value of these markers for sepsis.Conclusion Continuous mild sedation results in shortened length of stay in the ICU and decreased inflammatory response in the treatment of patients with multiple trauma.%目的 比较轻度持续镇静和常规镇静对ICU多发伤患者镇静效果和炎症反应的影响. 方法 采用前瞻性随机对照方法,将2013年10月一2015年4月江苏大学附属人民医院收治的58例多发伤患者按照随机信封法分为轻度持续镇静组(持续组,30例)和常规镇静组(常规组,28例).比较两组患者机械通气使用持续时间、住ICU时间、连续肾脏替代治疗(CRRT)使用率、气管切开率、气管插管意外拔管率、脓毒症发生率、多脏器功能衰竭(MOF)发生率、病死率等.并测定入住ICU后24,48,72 h炎性指标变化. 结果 两组患者病死率差异无统计学意义,持续组死亡3例(10%),常规组死亡4例(14%)(P>0.05).持续组机械通气时间短于对照组[(4.8±2.7)d:(8.9±3.1)d](P<0.01),持续组住ICU时间短于对照组[(10.7±5.4)d:(16.9±7.3)d](P<0.01).两组患者CRRT、气管切开率、气管插管意外拔管率、脓毒症发生率和MOF发生率差异无统计学意义.持续组血清炎症因子白细胞介素(IL)-6、肿瘤坏死因子(TNF)-α、C反应蛋白(CRP)水平在24,48,72 h低于常规组,仅48 h时比较,差异有统计学意义(P<0.05).相应时间段血清IL-10水平持续组高于常规组(P<0.05).持续组入住ICU 48 h血清IL-6、IL-10、TNF-α、CRP水平在受试者工作特征(ROC)曲线下面积(AUC)分别为0.726,0.608,0.729,0.757,对脓毒症有一定预测价值. 结论 轻度持续镇静对多发伤患者是可行的,可以缩短住ICU时间,减轻炎症反应.
    • 周光居; 刘善收; 赵光锋; 赵嵩; 张茂
    • 摘要: Objective To investigate the effect of optimized radiological examination strategy on iatrogenic radiation exposure in severe trauma patients so as to provide scientific basis for standardized application of radiological examination.Methods A controlled, three-stage intervention study from April 2010 to November 2011 was carried out.From April 2010 to July 2010, a pre-intervention study was conducted and enrolled 60 patients [43 males, 17 females;age (50 ± 14)years, age range 23-78 years].From August 2010 to March 2011, optimized strategies of radiological examination were implemented, including improving clinicians' knowledge to the standardization of radiological examination and iatrogenic radiation injury and limiting frequency of CT scans through the electronic medical record.From April 2011 to November 2011, post-intervention study was conducted and enrolled 100 patients (81 males, 19 females;age (47 ± 14) years, age range 18-79 years].During this period, major trauma patients were analyzed with respect to the clinical information, radiation examination frequency, ionizing radiation dose and influencing factors.Radiation examination frequency and radiation dose were compared before and after the intervention.Results Radiological examinations were mainly X-ray and CT before the implication of optimized strategies.Of the 60 patients, median frequency of X-rays and CT scan was 6.0(3.0-11.0) and 10.0(8.0-13.8).Median frequency of CT scan was positively correlated with the injury severity score (ISS) and ICU length of stay (r =0.369 and 0.523, P < 0.05).Of the 100 patients, median frequency of CT scan was significantly reduced after the optimization of radiological examination (8.0 vs.10.0, P < 0.05).Total frequency of radiological examination was significantly reduced as well (13.6 vs.17.8, P <0.01).There was no significant difference in the treatment success rate before and after the optimization of radiological examination (85.0% vs.88.3%, P > 0.05).When the frequency of head and chest CT scan was limited, the frequency of radiological examination, radiation exposure and radiological examination expenses were greatly reduced.Conclusions Too much X-ray,CT or other radiological examinations are noted in major trauma patients during the treatment period.Improved understanding of radiation-induced injury, optimizing radiological examination and controlling the repeated radiological examinations of the same site contribute to reducing iatrogenic radiology exposure without affecting the outcome.%目的 探讨采取优化的放射学检查策略对严重创伤患者医源性辐射暴露量的影响,为进一步规范创伤的放射学检查提供依据. 方法 本研究为临床干预前后对照研究.2010年4月-2011年11月分三个阶段实施:2010年4-7月进行干预前调查(第一阶段),共纳入60例患者,其中男43例,女17例;年龄23 ~78岁[(50±14)岁].2010年8月-2011年3月逐步实施优化的放射学检查策略(第二阶段),包括加强临床医师对创伤放射学检查规范及医源性辐射损伤的认识、通过电子病历系统限制患者CT检查部位数.2011年4-11月为干预后观察(第三阶段),共纳入100例患者,其中男81例,女19例;年龄18 ~ 79岁[(47±14)岁].收集研究期间严重创伤患者的临床信息、放射学检查的次数、辐射剂量和影响因素,比较干预前后患者放射学检查的次数和辐射剂量的变化. 结果 (1)第一阶段60例患者住院期间接受的放射学检查主要为X线片和CT检查,人均摄片6.0次(四分位数3.0~11.0次),CT检查10.0次(8.0~13.8次),CT检查次数与损伤严重度评分(ISS)和ICU住院天数相关(r=0.369,0.523,P均<0.05).(2)第三阶段100例患者人均CT检查次数较第一阶段显著减少(8.0次:10.0次,P<0.05),总放射学检查次数也减少(13.6次:17.8次),P<0.01,救治成功率无明显变化(85.0%:88.3%),P>0.05.(3)控制患者头颅及胸部CT复查次数,进一步降低了放射学检查次数、辐射暴露和放射学检查费用. 结论 严重创伤患者救治期间接受较多的放射学检查,应提高临床医师对辐射损伤的认识、优化放射学检查制度、减少同一部位复查次数,可有效减少患者的医源性辐射暴露而不影响救治效果.
    • 郝继山; 季庆; 孙清; 刘暌
    • 摘要: 目的 探讨颅脑损伤合并多发伤患者的液体复苏策略. 方法 回顾性分析2007年1月-2013年1月收治的124例颅脑损伤(GCS 3~12分)合并多发伤患者的临床资料,依据液体复苏策略分为积极液体复苏组(AFR组,63例)和限制性液体复苏组(LFR组,61例).补液的量化调控标准:严密监测血流动力学,LFR组将平均动脉压(MAP)控制在70 ~ 80 mmHg,中心静脉压控制在6~8 cmH2O,维持48 h;AFR组MAP控制在患者基础血压水平,中心静脉压控制在8~12 cmH2O,余治疗两组基本相同.比较两组血压水平、休克状况、凝血功能、影像学资料、GCS、伤后6个月GOS等指标. 结果 两组入院时MAP、休克指数、ISS、创伤严重指数(TSI)、GCS差异均无统计学意义(P>0.05),LFR组的血压波动水平(18.5±9.9) mmHg,小于AFR组的(29.4±11.1)mmHg (P<0.01).LFR组颅内出血进展8例,开颅手术3例,少于AFR组颅内出血进展19例及开颅手术10例(P<0.01).LFR组凝血功能指标好于AFR组(P<0.05).入院7 d LFR组GCS为(9.1±3.6)分,AFR组为(7.2±2.3)分(P<0.05).随访6个月时LFR组预后良好34例,不良27例;AFR组预后良好23例,预后不良40例,LFR组好于AFR组(P<0.05). 结论 对于中、重型颅脑损伤合并多发伤患者,LFR可改善凝血功能障碍和休克,降低颅内再出血概率,对改善预后有一定的帮助.%Objective To investigate the fluid resuscitation strategies to craniocerebral injury patients combined with multiple trauma.Methods This retrospective review was made on 124 patients with combined craniocerebal injury (GCS 3-12 points) plus multiple trauma.Based on the fluid resuscitation strategies,63 patients were treated with aggressive fluid resuscitation (AFR),and 61 with limited fluid resuscitation (LFR).A restrictive rehydration principle was performed with intensive hemodynamic monitoring:mean arterial pressure was kept between 70-80 mmHg for 48 hours and central venous pressure between 6-8 cmH2O for 48 hours in LFR group; mean arterial pressure was kept in basic level and central venous pressure between 8-12 cmH2O in AFR group.No significant differences were shown in the rest of treatments.Parameters were compared between groups such as blood pressure,shock index,coagulation function,imaging data,GCS,and GOS at 6 months postinjury.Results Between-group differences were insignificant with regard to mean arterial pressure (MAP),shock indices,ISS,trauma severity indices (TSI),and GCS (P >0.05).Blood pressure fluctuation in LFR group was (18.5 ±9.9) mmHg vs (29.4 ± 11.1) mmHg in AFR group (P < 0.01).Eight patients developed intracranial hemorrhage progression in LFR group,with 3 being treated with craniotomy.In comparison,19 patients developed intracranial hemmorrhage progression in AFR group,with 10 being treated with craniotomy (P < 0.01).Improvement in coagulation disorders was better in LFR group than in AFR group.On days 7 after admission,GCS in LFR groups was (9.1 ± 3.6) points vs (7.2 ± 2.3) points in AFR group (P <0.05).At 6-month follow-up,results were 34 good and 27 poor in LFR group,better than 23 good and 40 poor in AFR group.Conclusion For moderate to severe craniocerebral injury combined with multiple trauma,LFR is effective to treat coagulation disorders and hemorrhagic shock,reduce the probability of delayed intracranial hemorrhage,and further improve the outcome.
    • 李春萌
    • 摘要: 目的:探讨多发伤合并失血性休克液体复苏的方法。方法将多发伤合并失血性休克患者80例根据休克复苏方法的不同分为常规液体复苏组( A组)和限制性液体复苏组( B组)各40例。比较液体复苏45、90、135min后2组动脉血气分析结果、血清乳酸含量、凝血功能情况;比较液体复苏135min后2组肝肾功能、肿瘤坏死因子α、心肌酶谱、血细胞比容,总输液量、失血量、输血量,多器官功能障碍综合征、弥漫性血管内凝血的发生率及病死率。结果 B组氧分压、pH值、碱剩余明显高于A组同时间点,二氧化碳分压、血清乳酸明显低于A组同时间点(P﹤0.05);B组凝血功能指标均优于A组同时间点(P﹤0.05)。复苏135min后,B组肝肾功能、肿瘤坏死因子α、肌酸激酶同工酶、肌酸激酶、血细胞比容明显低于A组(P﹤0.05),总输液量、失血量、输血量明显少于A组,多器官功能障碍综合征、弥漫性血管内凝血发生率及病死率与A组比较差异无统计学意义( P﹥0.05)。结论限制性液体复苏在多发伤合并失血性休克患者的救治中可获得良好效果,可有效改善患者血气分析、凝血功能等指标,减少输血量,为患者的后续治疗提供了有力保障。
    • 摘要: “我们希望再次表达对你们医院医术的强烈认可和及时救治的衷心感谢!”这段话来自莫桑比克驻中国大使馆送给江苏省南京市中西医结合医院的一封感谢信,该院在今年初用中西医结合疗法成功救治因车祸意外导致全身多处损伤的莫桑比克留学生凯尔顿。
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