targeting

摘要： After China eradicated absolute poverty in 2020,the problems of relative poverty and urban poverty will draw more attention.Social protection system in urban areas lays the groundwork for economic transition and social stability.The targeting accuracy of urban minimum livelihood guarantee(Dibao)system is the key to the success of the system.After analyzing urban Dibao’s targeting practice and performance with household survey data,this study found that the issuance of Dibao payments took account of household income,assets and demographic characteristics to ensure minimum livelihood guarantee and meet recipients’urgent needs.This practice is of great importance during China’s economic transition.Under the multidimensional review mechanism,the exclusion error of urban Dibao is in the range of 38.45% and 66.28%,and the inclusion error is between 54.59% and 69.17%.By 2013,Dibao’s targeting efficiency improved significantly over 2007.In evaluating Dibao’s targeting efficiency,it is more appropriate to adopt multidimensional criteria instead of income alone.Multidimensional evaluation is also of great importance for evaluating Dibao’s targeting policy.

摘要： Herbal compounds have enormous potential to enhance the efficacy of current cancer treatments.Several herbal compounds have been reported to enhance the effect of chemotherapy,hormonal therapy and gene therapy on tumor cells.Compared to synthetic formulations,natural products are considered safer and do not have toxic effects at therapeutic doses,thus increasing demand for them.These compounds can significantly effect on signal transduction pathways,reduce side effects,and even inhibit the efflux of anticancer drugs.This review will explain factors influencing herbal nanomedicines,targeting of nanomedicines,nanocarriers used for delivery,herbal nanomedicines in cancer,phytochemical based combinatorial nanomedicines,and challenges to the nanocarriers based cancer therapy.

摘要： Red blood cells(RBCs)are an excellent choice for cell preparation research because of their biocompatibility,high drug loading,and long half-life.In this study,doxorubicin(DOX)was encapsulated with RBCs as the carrier.The biotin-avidin system binding principle was used to modify biotinylated cyclic arginine-glycine-aspartic acid(cRGD)onto RBC surfaces for accurate targeting,high drug loading,and sustained drug release.The RBC drug delivery system(DDS)was characterized,and the concentration of surface sulfur in the energy spectrum was 6.330%.The physical and chemical properties of RBC DDS were as follows:drug content,0.857 mg/mL;particle size,3339 nm;potential value,
12.5 mV;and cumulative release rate,81.35%.There was no significant change in RBC morphology for up to seven days.The results of the targeting and cytotoxicity studies of RBC DDS showed that many RBCs covered the surfaces of U251 cells,and the fluorescence intensity was higher than that of MCF-7 cells.The IC50 value of unmodified drug-loaded RBCs was 2.5 times higher than that of targeted modified drug-loaded RBCs,indicating that the targeting of cancer cells produced satisfactory inhibition.This study confirms that the RBC DDS has the characteristics of accurate targeting,high drug loading,and slow drug release,which increases its likelihood of becoming a clinical cancer treatment in the future.

摘要： One of the main reasons for developing cancer drug-resistance is the ability of cancer cells to adopt mutations that help them fight the treatments. Cancer cells are very mutagenic. This makes the population of cancer cells in any tumor, or any other cancer cells that come from a distinct origin (one parent cell) highly variable. In some cases, there are already drug-resistant cancer cells at the beginning of the treatment. In other cases, they emerge during the treatment. Treating cancer patients with drugs, or other treatments that attack only one cancer-target would therefore be prone to bad prognosis. In addition, these kinds of treatments would also attack (to a lower degree) non-cancer cells that contain the same targets as the cancer cells. This would lead to adverse effects. Combination therapies, or bispecific drugs could partly solve these problems, but not completely. To address this and other problems, a novel concept for curing cancer, MuTaTo©, was developed. MuTaTo is a personalized medicine concept. The main principal of it is using multiple targeting peptides connected together with a toxin. The main advantage of MuTaTo is that it would lower the probability of the targeted cancer cells to develop drug-resistance due to mutations they possess, and at the same time would lower adverse effects due to avidity effect. Each cancer patient would receive a specific MuTaTo drug perfectly suited to his cancer, based on the expression profile of receptors on the outer membrane of his cancer cells. MuTaTo construct production is easy and rapid. Therefore, the production cost would not be as expensive as with other biological drugs, or other sophisticated cancer treatments. In this article several experiments were performed to show the efficacy of different MuTaTo constructs, and the sustainability of the principals of this concept. The results showed that multi-targeting was better than mono targeting, and that MuTaTo was efficient as a mono treatment in vitro, and in vivo.

摘要： Estrogen receptor alpha(ERα/ESR1)is overexpressed in over half of all breast cancers and is considered a valuable therapeutic target in ERαpositive breast cancer.Here,we designed a membrane-permeant Chaperonemediated Autophagy Targeting Chimeras(CMATAC)peptide to knockdown endogenous ERαprotein through chaperone-mediated autophagy.The peptide contains a cell membrane-penetrating peptide(TAT)that allows the peptide to by-pass the plasma membrane,anαI peptide as a protein-binding peptide(PBD)that binds specifically to ERα,and CMA-targeting peptide(CTM)that targeting chaperone-mediated autophagy.We validated that ERαtargeting peptide was able to target and degrade ERαto reduce the viability of ERαpositive breast cancer cells.Taken together,our studies provided a new method to reduce the level of intracellular ERαprotein via CMATAC,and thus may provide a new strategy for the treatment of ERαpositive breast cancer.

摘要： A totally structure-determined organosilver(I) metal-oganic framework(MOF) of [{Ag18(CF3COO)18(H2O)2}{Ag4(erlotinib)4}]n·7nCH3OH·3nH2O(1) was first synthesized by the self-assembly of erlotinib drug ligand and silver salts in the study. 1 formed a NbO-like 3D network, which was built from Ag(I)-erlotinib induced chains and 18-core silver(I) nanoclusters. When 1 was dispersed in methanol solution, it formed derivative nanoparticles(1-NPs) with the average size of 3.81 nm. Silver(Ⅰ) ion is an efficient reactive oxygen species(ROS) evocator, whereas the erlotinib ligand possesses the targeting activity towards tumor cells. Therefore, IC50 values of 1-NPs for A549 and MRC-5 cells were respectively 0.97 and 7.28 μM, which were lower than IC50 value of erlotinib. It should be noted that the 7.5-fold higher inhibition effect on A549 cells allows 1-NPs to be a potential targeting anticancer drug for curing lung cancer. The study opens a new avenue to design anticancer drugs based on organosilver(I)MOF derivatives that can realize the value-added reactivity by combining clinical drugs with ROS-inductive silver(Ⅰ) ion.

摘要： At this years annual two sessions of the National People's Congress (NPC) and the National Committee of the Chi nese People's Political Consultative Conference (CPPCC), NPC deputies and CPPCC National Committee members spent much time deliberating and discussing the important issue of poverty alleviation. China has set the goal of eradicating abso lute poverty by 2020. In this context, 2019 is an important year to edge closer to the goal.

摘要： Background: Distortion of the Leksell stereotactic frame can occur during surgical and radiosurgical frame-based procedures. The targeting accuracies of surgical procedures such as DBS surgery or frame-based biopsy, or Gamma Knife radiosurgical procedures, are related to the stereotactic frame that is commonly referred to a non-deformable referential system. Objective: To evaluate the clinical impact of frame distortion on accuracy of targeting in various stereotactic procedures. Methods: We studied the influence of increasing levels of distortion of the Leksell frame both on surgical procedures using the stereotactic arch, and on radiosurgical procedures with the Gamma Knife. For surgical procedures we applied the Target Simulator of Elekta to a frame submitted to different levels of frame distortion, and we measured the modifications of accuracy of targeting. For radiosurgical procedures the Leksell frame was applied on an anthropomorphic phantom and modifications of target coordinates were measured by an imaging method using the stereotactic CBCT of the Gamma Knife ICON. Results: For surgical procedures, we found a linear relation between the amount of the frame distortion and the extent of the deviation from the stereotactic target using the stereotactic arch (R2 = 0.99709). The level of bending of the frame is also linearly related to the level of inaccuracy of stereotactic targeting based on acquisition of MRI and CTscan with the Elekta imaging boxes (R2 = 0.96825). The inaccuracy of targeting related to frame bending can be avoided by a systematic control at the end of frame placement and by the use of the CBCT of the Gamma Knife Icon. Conclusion: Distortion of the frame is a significant source of clinical inaccuracy of targeting for stereotactic procedures. Frame bending must be checked after each frame placement and corrected if needed to avoid targeting inaccuracy during stereotactic surgery and radio-surgery procedures.

摘要： 由上海生命科学研究院博士生陈树清和中国农业科学院蚕业研究所侯成香副研究员共同撰写的研究论文“Transgenic CRISPR/Cas9-mediated viral gene targeting for antiviral therapy of Bombyx mori nucleopolyhedrovirus（BmNPV）”（CRISPR/Cas9介导的基因打靶技术获得对核型多角体病毒高抗的转基因家蚕）,日前在国际病毒学的权威期刊《病毒学杂志》（Journal of Virology）上发表.

摘要： The rising cost of energy and environmental concerns have led the brewing industry to search for techniques of reducing energy consumption in brewery operations. In this paper, pinch analysis was applied to a typical Ugandan based brewery process to target for the energy requirements of the process. Hint software was used for the analysis. At the chosen ΔTmin of 10°C, the minimum cooling and heating utility requirements of the brewery studied were determined as being 4862.21 kW and 8294.21 kW respectively, with a pinch temperature at 68°C. It was observed that using the technique, 1806.59 kW of energy could be recovered through process to process heat exchange which presented an energy saving potential of 21.5%. It is recommended that results from this study could be used in the design or retrofit of a heat exchanger network of a brewery for improved energy efficiency. Considerations can also be made for other values of ΔTmin.

摘要： 本发明公开一种tgt的iSCSI‑target配置全局化的管理方法，包括S100，集群中创建共享的target配置信息的存储池，在存储池中创建target配置文件；S200，集群节点配置新的target时，检查所述target配置文件和集群节点内存，删除检索到的相匹配的失效target，将新的target配置信息写入所述target配置文件；S300，集群节点访问target时，检查所述target配置文件和内存，根据target配置文件中的target信息，创建连接；S400，集群节点删除target时，检查所述target配置文件和内存，删除检索的相匹配的target。本发明将tgt的iSCSI‑target配置信息持久化至分布式集群，不需要消耗额外的带宽和操作进行节点之间的配置信息的同步；涉及到的target操作均对配置文件和集群内存检查，排除无效的target相关信息的干扰，保证集群正常对客户端提供服务。

摘要： 本发明提供了一种分布式存储系统中ISCSI Target负载均衡方法和装置，分布式存储系统包括管理节点和数据节点，每个数据节点中均部署多个ISCSI Target，该方法应用于管理节点，包括：监控所有数据节点中的ISCSI Target的使用状态；根据每个数据节点中各ISCSI Target的使用状态确定该数据节点的负载量；根据所有数据节点中的ISCSI Target的使用状态确定所有数据节点的平均负载量；针对每个数据节点，根据该数据节点的负载量和所述平均负载量对该数据节点执行负载均衡操作。本发明能够解决分布式存储系统的负载均衡问题。

摘要： 本发明提供一种基于Target‑Aspect‑Opinion联合抽取的短文本评论情感分析方法。本发明首先对短文本数据集进行预处理，筛选有效数据，然后对数据集进行预标注工作，然后构建基于Target‑Aspect‑Opinion联合抽取的情感分析模型。本发明提出的联合抽取模型，解决了现有模型中单独抽取Target或Aspect等带来的识别不全面问题，以及通过构建TargetTaggers和Aspect‑OpinionTaggers，有效解决了目标词重叠问题。

摘要： 本发明提供一种基于TOE网卡的Target端协议硬件解析方法，发起端经TOE网卡向目标端发送ISCSI PDU，网卡的FPGA对TCP payload数据流进行PDU帧界定，找出BHS字段和AHS字段与数据段；AHS字段和数据段写入TOE网卡DDR，BHS字段写入Host DDR；网卡的驱动层对获取的BHS字段，判断BHS字段长度是否大于预设值，若判断为是，则驱动层将PDU剩余信息传至Host DDR；若判断为否，则应用层将Host DDR中PDU全部信息传至CPU。本发明对ISCSI PDU的BHS字段和AHS字段与数据段进行分流处理，与传统方式相比，明显降低CPU负载并提升整体传输效率。

摘要： 本申请公开了一种分布式存储集群的target管理方法，应用于分布式存储集群的主节点中，包括：接收target创建请求；通过解析target创建请求得到配置信息，并基于配置信息生成用于创建target的消息；将生成的消息置入消息队列中，以使得分布式存储集群中的每一个从节点在监听到消息之后进行target的创建。应用本申请的方案，可以在分布式存储集群中进行target的快速创建，且不会过度占用主节点的资源。本申请还公开了一种分布式存储集群的target管理相关组件，具有相应技术效果。

摘要： 本发明提供了一种iscsi target多路径分组的方法、装置、设备及可读介质，该方法包括：响应于iscsi target的管理工具启动，获取后端存储集群的节点信息；将获取到的节点信息填入节点分配表中并初始化节点分配表；响应于接收到创建逻辑卷映射的指令，基于用户设置的路径数选择节点分配表中路径数最少的存储节点进行分配；更新节点分配表。通过使用本发明的方案，能够使所有target的路径均匀的分散在后端存储节点上，减少不同target间路径的影响，充分发挥存储节点的读写性能。

摘要： 本发明提供一种基于Target‑Aspect‑Opinion联合抽取的短文本评论情感分析方法。本发明首先对短文本数据集进行预处理，筛选有效数据，然后对数据集进行预标注工作，然后构建基于Target‑Aspect‑Opinion联合抽取的情感分析模型。本发明提出的联合抽取模型，解决了现有模型中单独抽取Target或Aspect等带来的识别不全面问题，以及通过构建TargetTaggers和Aspect‑OpinionTaggers，有效解决了目标词重叠问题。

摘要： 本发明涉及计算机技术领域并提供了Target端的选择方法、分布式集群系统及计算机可读介质，该Target端的选择方法用以对分布式集群系统中节点自客户端发起访问请求予以响应的节点中的运行Target进程的Target端予以选择；选择方法包括监控节点的使用状态并保存，接收自客户端的Initiator进程下发的配置策略，调用节点的使用状态并根据节点选择策略确定匹配与自客户端发起访问请求相适应的Target端。本发明能够在分布式集群系统中各个节点与客户端之间断开时，从分布式集群系统中自动选取可用的Target端，避免了在选取可用的Target端后对整个分布式集群系统各个节点间资源配置不均衡的问题。

摘要： 本发明提供了一种iscsi target tgt架构优化方法及系统。该方法包括：在加载iscsi驱动程序时，在iscsi target上已申请的内存空间中建立内存池；基于已经建立的内存池，完成对iscsi target上内存的物理IO。本发明提供的iscsi target tgt架构优化方法及系统能够使得IO读写稳定性提升、性能提升。

摘要： 本发明涉及一种实现嵌入式VxWorks系统更改IP地址后建立target server的方法，属于嵌入式软件开发领域。本发明在VxWorks集成开发环境中，创建一个静态库工程；在静态库工程源程序中，定义一个函数；在函数中声明“传入启动参数”结构变量，并对变量进行赋值；调用WDB初始化函数和WDB系统悬挂函数；编译静态库工程生成静态库文件；将静态库添加到应用软件中，在执行连接target server之前，调用静态库的入口函数。本发明提高了VxWorks嵌入式操作系统连接target server，通过网络进行调试的适用性，方便了应用程序的开发调试，增强了硬件环境对软件开发调试的支撑性，本发明可在应用软件更改网卡IP地址的情况下，仍可实现target server的连接，该方法可行性强，稳定可靠。