摘要：
光声成像是一种基于光学方法激发样品产生超声信号的新型成像方式,兼备光学高对比度和超声大穿透深度与高分辨率优势,同时具有光谱信息获取能力,可对血红蛋白、脂质成分、血氧代谢等分子和功能信息进行高特异性获取,实现结构与功能性成像,敏锐捕捉相关生理特征变化;同时,得益于其跨尺度成像能力,光声成像可以灵活实现多种成像模式.光声成像技术的这些特点,使其在恶性肿瘤、动脉粥样硬化、微循环异常等重大疾病相关的临床诊断和病理研究中,具有广泛应用潜力,正得到生物医学领域越来越多的关注.本文将主要介绍中国科学院深圳先进技术研究院团队在光声成像技术临床转化方面的主要研究工作,包括微血管成像、血管介入成像、消化道内窥成像、前哨淋巴结成像等方面的最新研究进展.%Photoacoustic imaging is a novel imaging modality that utilizes pulsed laser to illuminate samples and ultrasonic transducers for detection of the laser absorption generated ultrasonic/photoacoustic waves. Benefited from its high optical contrast and acoustic resolution at depth, as well as the capability of acquiring optical spectral information, photoacoustic imaging allows for structural and functional imaging of the biological relevant information such as hemoglobin concentration, blood oxygen metabolism, and lipid with high specificity, and is able to capture the corresponding physiological feature dynamics with high sensitivity. In terms of the imaging system, photoacoustic imaging manifests a variety of embodiments catering the multi-scale biomedical imaging needs. The above mentioned features and capabilities enable extensive biomedical application potentials of this imaging modality in both clinical diagnosis and pathological analysis, such as malignant tumor detection, atherosclerotic plaque assessment, and microcirculation abnormality diagnosis. Therefore, it is attracting more and more attention and interests in a wide range of biomedical research areas. This article presented the recent progress of photoacoustic technology development and application studies in our group in the fields of microvascular imaging, intravascular imaging, gastrointestinal endoscopic imaging, and sentinel lymph node imaging.
