Objective: To assay antiviral effects of the polysaccharide and its separated products from Sargassum fusiforme on HSV-1 and CVB3 and their antiviral mechanism. Method: The antiviral effects of all samples on HSV-1 and CVB3 and their cytotoxicity on Vero cells were studied by CPE and MTT method. Antiviral mechanism of two samples was briefly studied by four different ways. Results: (c) The cytotoxicity of samples on vero cells was not detected (CC>5000?g/mL). (c) All samples except PSJ had obviously HSV-1 inhibitory effect. Antiviral activities of them were increasingly strengthened with raising their purities. Antiviral activities of F1, F2 and F4 were better than ACV. ? Antiviral activities of all samples on CVB3 were better than ribavirin injection. F1, F2 and F4 had remarkable anti-CVB3. (?) The experiment showed that polysaccharide not only able to kill the above viruses directly but also restrain them by getting into cell or absorbing on cells.
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