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首页> 外文会议>13th International Symposium on Ceramics in Medicine and the Annual Meeting of the International Society for Ceramics in Medicine 22-26 November 2000 Bologna, Italy >Development of Revolutionizing Methods for Hybrid-Type Artificial Organs by Means of Bioceramics and Biomechanics
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Development of Revolutionizing Methods for Hybrid-Type Artificial Organs by Means of Bioceramics and Biomechanics

机译：利用生物陶瓷和生物力学研究混合型人工器官的革新方法

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摘要

The phylogenetic transition of branchiae into the lung as well as the migration of hemopoietic activity from the spleen to the bone marrow cavity demonstrate the concurrent evolutionary changes of organs structures and functions in vertebrates in response to the effect of gravity during terrestrialization from a water environment. The present study introduces a hybrid-type artificial bone marrow chamber that uses sintered hydroxyapatite (HA) and titanium electrode, which is able to induce hemopoietic nest formation in conjunction with osteogenesis not only heterotopically in mammalian muscle, but heterospecifically in archetype vertebrates, which have no bone marrow hemopoiesis in inner skeletons. As well the gomphotic tooth system developed during the third revolution of the vertebral evolution by biomechanical stimuli. i.e., by corresponding of teeth and jawbones of animals to the masticatory movements. The authors developed artificial root of corrugated cone shape using sintered compact hydroxyapatie (HA), which could induce to be gomphotic as well as ankylotic binding system depending on biomechanical stimuli of occlusal function or complete rest of implanted root after operation. Following results are obtained: Bone marrow hemopoiesis in artificial chambers could be observed heterotopically in all cases. Gomphotic artificial roots with cementum were developed by biomechanical stimuli in the solid diet group. Ankylotic artificial roots were obtained in complete test roots by the soft diet group.
机译：ia科动物向肺部的系统发育过渡以及造血活动从脾脏向骨髓腔的迁移表明，脊椎动物的器官结构和功能同时发生进化变化，这是对水环境中陆地化过程中重力作用的响应。本研究介绍了一种混合型人工骨髓腔室，该腔室使用烧结的羟基磷灰石（HA）和钛电极，不仅能够在哺乳动物肌肉中异位，而且在原型脊椎动物中具有异种特异性，从而能够诱导造血巢的形成以及成骨作用。内部骨骼无骨髓造血。同样，通过生物力学刺激，在椎骨进化的第三次旋转过程中，形成了牙髓系统。即通过使动物的牙齿和颚骨与咀嚼运动相对应。作者使用烧结的致密羟基磷灰石（HA）开发出了波纹状圆锥形的人工根，根据咬合功能的生物力学刺激或手术后植入的根的完全其余部分，可以诱导成线状和强直性结合系统。获得以下结果：在所有情况下，都可以异位观察到人工房中的骨髓造血。固结饮食组通过生物力学刺激发展了具有牙骨质的可塑人工根。软饮食组在完全测试的根中获得了强直人工根。

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