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首页> 外文会议>13th International Symposium on Ceramics in Medicine and the Annual Meeting of the International Society for Ceramics in Medicine 22-26 November 2000 Bologna, Italy >In Vivo Resporption Behavior of a High Strength Injectable Calcium-Phosphate Cement
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In Vivo Resporption Behavior of a High Strength Injectable Calcium-Phosphate Cement

机译：高强度可注射磷酸钙水泥的体外重塑行为

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摘要

A high strength calcium-phosphate-cement powder was prepared from a composition comprising of alpha-TCP, CaHPO_4 (monetite), CaCO_3 and some seeds of precipitated apatite. An aqueous solution of 4percent Na_2HPO_4 was used as liquid to start the setting reaction. The powder was mixe with ceemnt liquid in three different liquid/powder ratios respectively 0.3, 0.35 and 0.4. Observation of the setting reaction versus time revealed that the maximum of compressive strength was achieved after 3 days reaching the value of 81 MPa. The X-ray diffraction pattern of the Ca-P cement measured 3 days after mixing and storage in Ringer's solution at 37 deg C showed that the alpha-TCP was transformed to hydroxylapatite with superposition of the peaks for monetite. XRD showed that after eight weeks of implantation the monetite peaks had disappeared. Further, the clinical handling properties of all three types of Ca-P cement appeared to be excellent. No problems in setting time or cavity filling were met during the application. The histological evaluation after two weeks of implantation showed abundant bone apposition on the cement surface without inflammatory reaction. At later time points the Ca-P cements were totally covered by a thin layer of bone and osteoclast-like cells in remodeling lacunae at the interface were resorbing the cement. At all implantation periods the PMMA controls showed the presence of a thin fibrous membrane.
机译：由包含α-TCP，CaHPO_4（透沸石），CaCO_3和一些沉淀的磷灰石种子的组合物制备高强度磷酸钙水泥粉末。使用4％Na_2HPO_4的水溶液作为液体开始凝固反应。将粉末与ceemnt液体以三种不同的液体/粉末比率分别为0.3、0.35和0.4混合。观察固化反应对时间的变化表明，在3天后达到81 MPa的值达到了最大的抗压强度。 Ca-P水泥的X射线衍射图谱在混合和在37℃的林格氏溶液中储存3天后测得，表明α-TCP转化为羟基磷灰石，其峰叠加了透钙磷石。 X射线衍射表明，植入八周后，芒硝峰消失了。此外，所有三种类型的Ca-P水泥的临床处理性能似乎都非常好。在应用过程中，设置时间或腔填充没有问题。植入两周后的组织学评估显示，在骨水泥表面有大量骨并存，没有炎症反应。在稍后的时间点，Ca-P水泥完全被薄薄的骨层覆盖，界面处重塑的腔隙中的破骨细胞样细胞正在吸收水泥。在所有植入期，PMMA对照均显示出纤维膜的存在。

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