首页> 外文会议>13th International Symposium on Ceramics in Medicine and the Annual Meeting of the International Society for Ceramics in Medicine 22-26 November 2000 Bologna, Italy >In Vivo Comparison of Two Injectable Calcium Phosphate Biomaterials: Ionic Cement and Polymer-Associated Particulate Ceramic
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In Vivo Comparison of Two Injectable Calcium Phosphate Biomaterials: Ionic Cement and Polymer-Associated Particulate Ceramic

机译:两种可注射磷酸钙生物材料的体内比较:离子水泥和聚合物缔合的颗粒陶瓷

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The present study compared the in vivo behavior of an ionic calcium phosphate bone cement and an composite injectable bone substitute (IBS) associating a biphasic calcium phosphate (BCP) mineral phase and a cellulosic polymer. Three weeks after implantation in rabbit bone, both biomaterials expressed biocompatibility and biocactivity but new bone formation and ceeramic degradation were significantly hgiehr for IBS than for the tested ionic cement. With IBS, newly-formed bone developed joining the BCP particles the ones to the others whereas new bone only grew on the surface of the cement that remained dense with no obvious degradation 3 weeks after implantation. This study confirms that BCP particles carried by a cellulosic polymer can conserve bioactivity and are conductive to earlier and more extensive bone substitution than a carbonated-HA bone cement. The presence of intergranular spaces in the IBS seemed particularly favorable since each BCP granule can be reached by body fluids immediately after implantation. Thus, the IBS seemed to function as a completely interconnected ceramic with total open macroporosity
机译:本研究比较了离子磷酸钙骨水泥和将双相磷酸钙(BCP)矿物相与纤维素聚合物结合的复合可注射骨替代品(IBS)的体内行为。植入兔骨三周后,两种生物材料均表现出生物相容性和生物活性,但IBS的生骨和陶瓷降解显着高于被测离子水泥。借助IBS,新形成的骨骼得以发展,将BCP颗粒彼此连接,而新的骨骼仅生长在粘固的水泥表面上,植入后3周没有明显降解。这项研究证实,由纤维素聚合物携带的BCP颗粒可以保留生物活性,并且比碳酸HA骨水泥具有更早,更广泛的骨替代作用。 IBS中存在晶间间隙似乎是特别有利的,因为每个BCP颗粒均可在植入后立即被体液到达。因此,IBS似乎起到了完全互连的陶瓷的作用,具有完全开放的大孔

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