New Development and Requirement of Indole Chemistry-Syntheses of Indolenine Derivatives

机译：吲哚化学的新发展和要求-吲哚衍生物的合成

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1.Introduction Indolenine itself has never been isolated,however,its derivatives are important intermediates in synthetic organic chemistry.Regioselective β-allylation of indole can be a pivotal step in many synthetic approaches toward the total synthesis of natural products,1,2 In the course of our studies toward the total synthesis of complex alkaloids which possess medicinal bioactivities,we realized that none of reported methods could transform functionalized indoles into β-Allyl indolenines under a mild condition.3-5 Recently,we have reported a general,high-yielding method for the palladium-catalyzed allylation of carba-and heterocycle fused indoles,including complex natural product substrates.6 Additional information about this research will be revealed in the lecture.

机译：1.引言吲哚肾上腺素本身从未分离出来，但是，其衍生物是合成有机化学中的重要中间体。吲哚的区域选择性β-烯丙基化可能是许多合成方法中向天然产物完全合成的关键步骤，1,2在研究具有药用生物活性的复杂生物碱的全合成过程中，我们意识到没有报道的方法可以在温和的条件下将功能化的吲哚转化为β-烯丙基吲哚。3-5最近，我们报道了一种通用的高钯催化的碳氢化合物和杂环稠合的吲哚，包括复杂的天然产物底物的烯丙基化反应的制备方法。6该研究的其他信息将在讲座中揭示。

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《18th International Symposium on Fine Chemistry and Functional Polymers,4th IUPAC International Symposium on Novel Materials and Their Synthesis(第18届国际精细化学和功能高分子学术讨论会暨第四届IUPAC 国际新型材料及其制备学术讨论会）》|2008年|76-77|共2页
会议地点 Zhenjiang(CN);Zhenjiang(CN);Zhenjiang(CN);Zhenjiang(CN)
作者
Natsuko Kagawa; Jeremiah P. Malerich; Ye Zhu; Viresh H. Rawal;
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作者单位

Graduate School of Materials Science,Nara Institute of Science and Technology (NAIST),8916-5,Takayama,Ikoma,Nara 630-0192,Japan;

Department of Chemistry,University of Chicago,5735 South Ellis Avenue,Chicago,Illinois 60637,USA;

Department of Chemistry,University of Chicago,5735 South Ellis Avenue,Chicago,Illinois 60637,USA;

Department of Chemistry,University of Chicago,5735 South Ellis Avenue,Chicago,Illinois 60637,USA;

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会议组织
原文格式 PDF
正文语种 eng
中图分类
关键词
Indole; β-Allylation; Palladium; Alkaloid;

机译：吲哚;β-烯丙基化;钯;生物碱;

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4. New Development and Requirement of Indole Chemistry-Syntheses of Indolenine Derivatives [C] . International symposium on fine chemistry and functional polymers . 2008

机译：吲哚胺衍生物吲哚化学合成的新发展和要求
5. I. Structure-based molecular modeling and synthesis of indole derivatives as non-phenolic analogues of mycophenolic acid. II. 3D-QSAR studies using CoMFA on homotropane and tropane derivatives as dopamine transporter and serotonin transporter ligands. [D] . El-Araby, Moustafa El-Sayed. 2001

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7. Development of Efficient Procedure for Indole Rings Synthesis from 2-Ethynylaniline Derivatives Catalyzed by Cu(II) Salts and Its Application to Natural Product Synthesis [O] . -1

机译：由Cu（II）盐催化的2-乙炔基胺衍生物合成的吲哚环合成的高效步骤及其在天然产品合成中的应用

New Development and Requirement of Indole Chemistry-Syntheses of Indolenine Derivatives

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