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首页> 外文会议>1996 Chinese Peptide Symposium July 21-25, 1996, Chengdu, China >Effect of arginine vasopressin AVP(4-8) on CaMKII autophosphorylation and CaM expression i nrat brain
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Effect of arginine vasopressin AVP(4-8) on CaMKII autophosphorylation and CaM expression i nrat brain

机译：精氨酸加压素AVP（4-8）对大鼠大脑CaMKII自磷酸化和CaM表达的影响

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摘要

The memory-enhancing peptide, AVP(4-8), existing in mammalian brain as a metabolite of arginine vasopressin (AVP), facilitates the short-term and long-term learnign and memory of animals. Significant acceleration of phosphorylated growth-associated protein (GAP43) maturation by AVP(4-8) [1] may be functionally involved in synaptic plasticity, axonelongation and long-term potetiation (LTP) [2]. Calmodulin (CaM) is a ubiquitous intracellular calcium receptor which can be released from CaM-binding proteins, such as GAP43 and MARCKS when they are phosphorylated by protein kinase C(PKC) [3]. CaM is responsible for activating more than 20 enzymes [4], among them Ca~2+/CaM-dependent auto-phosphorylation, CaMKII displays its protein kinase activity by switching the molecule into an "on" state. It has been found that LTP can be promptly induced by AVP(4-8) in rat hippocampual slices, but the process of LTP may not be necessarily related to the activation of NMDA receptor. So it is interesting to observe the changes of effctive CaM level and CaMKII activity in rat train when the animals are administered with AVP(4-8).
机译：记忆增强肽AVP（4-8）作为精氨酸加压素（AVP）的代谢产物存在于哺乳动物的大脑中，促进了动物的短期和长期学习和记忆。 AVP（4-8）[1]显着促进磷酸化生长相关蛋白（GAP43）的成熟，可能在功能上涉及突触可塑性，轴突伸长和长期造化（LTP）[2]。钙调蛋白（CaM）是一种普遍存在的细胞内钙受体，当它们被蛋白激酶C（PKC）磷酸化时，可以从诸如GAP43和MARCKS的CaM结合蛋白中释放出来[3]。 CaM负责激活20多种酶[4]，其中包括Ca〜2 + / CaM依赖的自磷酸化，CaMKII通过将分子切换为“ on”状态来显示其蛋白激酶活性。已经发现，大鼠海马切片中的AVP（4-8）可以迅速诱导LTP，但是LTP的过程可能不一定与NMDA受体的激活有关。因此，有趣的是在给动物注射AVP（4-8）后观察大鼠训练中有效CaM水平和CaMKII活性的变化。

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