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首页> 美国卫生研究院文献>Anatomy Cell Biology >Arginine vasopressin (AVP) expressional changes in the hypothalamic paraventricular and supraoptic nuclei of stroke-prone spontaneously hypertensive rats
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Arginine vasopressin (AVP) expressional changes in the hypothalamic paraventricular and supraoptic nuclei of stroke-prone spontaneously hypertensive rats

机译：卒中易发性高血压大鼠下丘脑室旁和视上核精氨酸加压素（AVP）的表达变化

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Arginine vasopressin (AVP) is a neuropeptide with vasoconstrictive, antidiuretic, cardiovascular regulative and hepatic glycogenolysis effects, that also affects other behaviors including modulating learning. A number of studies on AVP regulation have been conducted in various metabolic diseases (disorders). In this study, the immunoreactivities of AVP in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) and mRNA expressions in the hypothalamus were investigated by immunohistochemistry and quantitative real-time PCR (RT-qPCR) in stroke-prone spontaneously hypertensive rats at different ages (i.e., at postnatal months [PM] 1, 8, and 12). Blood glucose levels in the PM 8 group were higher than in the other groups. However, cresyl violet positive neurons were detected in the PVN and SON of all animals, and numbers of cresyl violet positive neurons were similar in all aged groups. In addition, AVP immunoreactivity was detected in the PVN and SON of all age groups, and AVP immunoreactivity and mRNA expression levels were found to be increased in proportion to age by immunohistochemistry and RT-qPCR. These results suggest that the diabetic condition is temporally generated after hypertension has developed. Furthermore, our findings suggest that increased AVP expressions in the hypothalamic PVN and SON are associated with hypertension by age.
机译：精氨酸加压素（AVP）是一种具有血管收缩，抗利尿，心血管调节和肝糖原分解作用的神经肽，它还影响其他行为，包括调节学习。在各种代谢性疾病（疾病）中进行了许多有关AVP调节的研究。在这项研究中，通过免疫组织化学和实时荧光定量PCR（RT-qPCR）研究了卒中易发性自发性高血压大鼠在脑室旁核（PVN）和视上核（SON）中AVP的免疫反应性以及下丘脑的mRNA表达。不同的年龄（例如，出生后[PM] 1、8和12月）。 PM 8组的血糖水平高于其他组。然而，在所有动物的PVN和SON中均检测到了甲酚紫阳性神经元，并且在所有老年组中甲酚紫阳性神经元的数量均相似。另外，在所有年龄组的PVN和SON中均检测到AVP免疫反应性，并且通过免疫组织化学和RT-qPCR发现AVP免疫反应性和mRNA表达水平与年龄成正比。这些结果表明糖尿病状况是在高血压发展之后暂时产生的。此外，我们的研究结果表明，下丘脑PVN和SON中AVP表达的增加与年龄有关。

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