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首页> 外文期刊>Neurochemical Research >Enhanced Expressions of Arginine Vasopressin (Avp) in the Hypothalamic Paraventricular and Supraoptic Nuclei of Type 2 Diabetic Rats
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Enhanced Expressions of Arginine Vasopressin (Avp) in the Hypothalamic Paraventricular and Supraoptic Nuclei of Type 2 Diabetic Rats

机译：2型糖尿病大鼠下丘脑室旁和视上核中精氨酸加压素（Avp）的增强表达

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摘要

Arginine vasopressin (AVP) is known to a neuropeptide that plays important roles in water conservation, sodium homeostasis, and in the regulation of serum osmolality. Several studies have reported that the elevated AVP level is related with diabetes mellitus as an acute or chronic stressor using type 1 diabetes mellitus animal models. However, it is unclear as to how the immunoreactivity and protein level of AVP in the brain is regulated in animal models of type 2 diabetes mellitus. In the present study, Zucker diabetic fatty (ZDF) rats were employed as a type 2 diabetes mellitus model and were compared with Zucker lean control (ZLC) rats with respect to AVP protein expression. Furthermore, in order to verify the regulation of AVP expression before and after the onset of diabetes mellitus, pre-diabetic rats (4 week-old) and obese-diabetic rats (12 week-old) were used. Blood glucose levels and water consumption were also measured and the results showed significantly high in 12 week-old ZDF than any other groups. AVP expression levels in the paraventricular nucleus and supraoptic nucleus were found to be significantly higher in 12 week-old ZDF rats than in 12 week-old ZLC rats and than in 4 week-old rats by immunostaining and western blotting. Enhanced expression of AVP in these animals may be associated with type 2 diabetes mellitus.
机译：精氨酸加压素（AVP）是一种神经肽，在节水，钠稳态和血清渗透压调节中起着重要作用。几项研究报道，使用1型糖尿病动物模型，AVP水平升高与糖尿病作为急性或慢性应激源有关。但是，尚不清楚在2型糖尿病动物模型中如何调节大脑中AVP的免疫反应性和蛋白质水平。在本研究中，采用Zucker糖尿病脂肪（ZDF）大鼠作为2型糖尿病模型，并就AVP蛋白表达与Zucker瘦对照组（ZLC）大鼠进行了比较。另外，为了验证糖尿病发作前后AVP表达的调节，使用了糖尿病前期大鼠（4周龄）和肥胖糖尿病大鼠（12周龄）。还测量了血糖水平和水消耗量，结果显示在12周龄的ZDF中，其血糖显着高于其他任何组。发现12周龄ZDF大鼠的室旁核和视上核中的AVP表达显着高于12周龄ZLC大鼠和4周龄大鼠的免疫染色和蛋白质印迹。这些动物中AVP表达的增强可能与2型糖尿病有关。

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  • 来源
    《Neurochemical Research》 |2008年第5期|833-841|共9页
  • 作者

    Sun Shin Yi; In Koo Hwang; Yo Na Kim; Il Yong Kim; Son-Il Pak; In Se Lee; Je Kyung Seong; Yeo Sung Yoon;

  • 作者单位

    Department of Anatomy and Cell Biology College of Veterinary Medicine and BK21 Program for Veterinary Science Seoul National University Seoul 151-742 South Korea;

    Department of Anatomy and Cell Biology College of Veterinary Medicine and BK21 Program for Veterinary Science Seoul National University Seoul 151-742 South Korea;

    Department of Anatomy and Cell Biology College of Veterinary Medicine and BK21 Program for Veterinary Science Seoul National University Seoul 151-742 South Korea;

    Department of Anatomy and Cell Biology College of Veterinary Medicine and BK21 Program for Veterinary Science Seoul National University Seoul 151-742 South Korea;

    Laboratory of Veterinary Clinical Pathology ampamp Epidemiology School of Veterinary Medicine Kangwon National University Chuncheon 200-701 South Korea;

    Department of Anatomy and Cell Biology College of Veterinary Medicine and BK21 Program for Veterinary Science Seoul National University Seoul 151-742 South Korea;

    Department of Anatomy and Cell Biology College of Veterinary Medicine and BK21 Program for Veterinary Science Seoul National University Seoul 151-742 South Korea;

    Department of Anatomy and Cell Biology College of Veterinary Medicine and BK21 Program for Veterinary Science Seoul National University Seoul 151-742 South Korea;

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  • 关键词

    Type 2 diabetes; Paraventricular nucleus; Supraoptic nucleus; Zucker rat; Arginine vasopressin;

    机译：2型糖尿病;室旁核;视上核;Zucker大鼠;精氨酸加压素;

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