Synthesis of amino acids selectively labelled with stable isotopes for application in peptide synthesis

机译：用稳定同位素选择性标记的氨基酸的合成，用于肽合成

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Amino acids labelled with stable isotopes such as ~2H, ~13C and ~15N were originally applied in metabolic studies and have subsequently played an important role also in many biosynthetic and mechanistic investigations. With the growing use of ~13C and ~15N NMR spectroscopy in strutural studies of proteins, isotope labelling has often become a major tool to increase the sensitivity as the natural abundance of these nuclei is only 1.1 and 0.35

机译：标记有稳定同位素（例如〜2H，〜13C和〜15N）的氨基酸最初用于代谢研究，随后在许多生物合成和机制研究中也发挥了重要作用。随着〜13C和〜15N NMR光谱在蛋白质结构研究中的越来越多的应用，同位素标记通常已成为提高灵敏度的主要工具，因为这些原子核的天然丰度仅为1.1和0.35

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来源
《1996 Chinese Peptide Symposium July 21-25, 1996, Chengdu, China》|1996年|p.22-24|共3页
会议地点 Chengdu(CN);Chengdu(CN)
作者
U.Ragnarsson; L.Grehn; Y.Elemes; B.Fransson;
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正文语种 eng
中图分类生物化学;
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机译：使用D-氨基酸脱氢酶有效合成具有稳定同位素的D-支链氨基酸及其标记的化合物
2. A class of novel nitronyl nitroxide labeling basic and acidic amino acids: synthesis, application for preparing ESR optionally labeling peptides, and bioactivity investigations. [J] . Zhang J, Zhao M, Cui G, Bioorganic and medicinal chemistry . 2008,第7期

机译：一类新型的可标记碱性和酸性氨基酸的硝酰基硝基氧：合成，用于制备ESR可选标记肽的应用以及生物活性研究。
3. Stereoselective synthesis of triply isotope-labeled ser, cys, and ala: Amino acids for stereoarray isotope labeling technology [J] . Terauchi T, Kobayashi K, Okuma K, Organic letters . 2008,第13期

机译：三重同位素标记的ser，cys和ala的立体选择性合成：用于立体阵列同位素标记技术的氨基酸
4. Synthesis of amino acids selectively labelled with stable isotopes for application in peptide synthesis [C] . U.Ragnarsson, L.Grehn, Y.Elemes, Chinese peptide symposium . 1998

机译：用稳定同位素选择性标记氨基酸的合成肽合成应用
5. Part 1. Synthesis of stable-isotope labeled amino acids; Part 2. Synthesis of mechanistic probes of retinoid action. [D] . Barnett, Derek W. 2002

机译：第1部分。稳定同位素标记的氨基酸的合成；第2部分。类维生素A作用的机械探针的合成。
6. Isotope labelling of Rubisco subunits provides in vivo information on subcellular biosynthesis and exchange of amino acids between compartments [O] . Doug K Allen, Russell W Laclair, John B Ohlrogge, -1

机译：Rubisco亚基的同位素标记提供了有关亚细胞生物合成和隔室之间氨基酸交换的体内信息
7. Synthesis of Novel Amino Acids and Use of Peptides Peptidomimetics Containing Unnatural Amino Acids for the Development of Selective Melanocortin Peptide Antagonists and for the Study of Melanocortin Receptor Signaling [O] . Qu Hongchang 2007

机译：新型氨基酸的合成以及含有非天然氨基酸的肽和拟肽在开发选择性黑皮质素肽拮抗剂和研究黑皮质素受体信号转导中的用途

Synthesis of amino acids selectively labelled with stable isotopes for application in peptide synthesis

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