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首页> 外文会议>1st International Conference on Orange Technologies >Combined structural and functional MRI studies in epilepsy with medial temporal lobe epilepsy
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Combined structural and functional MRI studies in epilepsy with medial temporal lobe epilepsy

机译：癫痫合并颞叶内侧癫痫的结构和功能MRI联合研究

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Epilepsy is a common neurological disorder, and its electrophysiology characteristic is abnormally high excitability and synchronization of the neural activity. This thesis focus on the study of medial temporal lobe epilepsy with hippocampal sclerosis. Hippocampus plays an important role in short term memory. However little is known about the connectivity between hippocampal structures and adjacent brain regions. Three pairs of region of interests (ROIs) related to working memory from the result of BOLD-fMRI data are chosen. These ROIs are registrated from montreal neurological institute template (MNI) space to individual space and the fiber bundle between two ROIs are traced in the diffusion tensor imaging (DTI) images. The results show that the number of fiber bundle has reduced among these ROIs, such as left hippocampus and right hippocampus, left hippocampus and left thalamus, left hippocampus and left frontal lobe and so on. And the number of fiber bundle has increased among these ROIs, such as left thalamus and right thalamus, right hippocampus and right thalamus. And the FA value of the fiber bundles in some regions related to left hippocampus has been decreased. The cause of abnormal functional and structural connections due to the damage of hippocampus in Medial temporal lobe epilepsy (mTLE) patients is studied from a new perspective view.
机译：癫痫病是一种常见的神经系统疾病，其电生理特征是异常高的兴奋性和神经活动的同步性。本文的研究重点是颞叶内侧癫痫伴海马硬化的研究。海马在短期记忆中起重要作用。然而，关于海马结构与相邻大脑区域之间的连通性知之甚少。从BOLD-fMRI数据的结果中选择与工作记忆相关的三对感兴趣区域（ROI）。这些ROI从蒙特利尔神经病学研究所模板（MNI）空间注册到各个空间，并且在扩散张量成像（DTI）图像中跟踪两个ROI之间的纤维束。结果表明，在这些ROI中，如左海马和右海马，左海马和左丘脑，左海马和左额叶等，纤维束的数量减少了。并且在这些ROI中，例如左丘脑和右丘脑，右海马体和右丘脑的纤维束数量增加了。并且在与左海马有关的某些区域中纤维束的FA值降低了。从一个新的视角研究了内侧颞叶癫痫（mTLE）患者由于海马体受损引起的功能和结构异常连接的原因。

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