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首页> 外文会议>2001 Workshop on the Utilization of Research Reactors Nov 5-9, 2001 Beijing, China >Research Efforts to Produce a ~(99)Mo-~(99m)Tc Generator using Reactor-Produced ~(99)Mo
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Research Efforts to Produce a ~(99)Mo-~(99m)Tc Generator using Reactor-Produced ~(99)Mo

机译：利用反应堆生产的〜（99）Mo生产〜（99）Mo-〜（99m）Tc发生器的研究工作

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Recognizing the importance of ~(99m)Tc and ~(99m)Tc-based radiopharmaceuticals in nuclear medicine, the Philippine Nuclear Research Institute has initiated research on the development of column-type generators for ~(99m)Tc using ~(99)Mo in the form of a gel. The use of reactor-produced ~(99)Mo will reduce the country's dependence on the importation of commercial generators based on fission product molybenum-99. However, the relatively low specific activity of ~(99m)Mo must be compensated by the high adsorption capacity of the column material for molybeneum. A procedure based on the incorporation of low activity ~(99)Mo into a zirconium molybdate gel matrix was adopted with reasonable success. Because the properties of the gel vary considerably with conditions of synthesis, the following parameters were carefully controlled: pH, concentration, temperature, order of mixing of the reactant solutions and conditions of aging, washing and drying of the zirconium-molybdate precipitate. The zirconium molybdate column was characterized mainly by elution yield data. Although the Institute's research work in this area has been shelved in the past five years, the goal of providing the country with cheaper source of Tc-99m for nuclear medical applications remains. It is hoped that the development of a new column material using reactor-produced molybenum-99 will fulfill this goal.
机译：认识到〜（99m）Tc和基于〜（99m）Tc的放射性药物在核医学中的重要性，菲律宾核科学研究所已开始研究使用〜（99）Mo开发〜（99m）Tc的柱型发生器的研究。以凝胶的形式。使用反应堆生产的〜（99）Mo将减少该国对基于裂变产物mobebenum-99的商业发电机进口的依赖。但是，〜（99m）Mo相对较低的比活度必须通过柱材料对钼的高吸附能力来补偿。采用了基于将低活性〜（99）Mo掺入钼酸锆凝胶基质的方法，并取得了一定的成功。由于凝胶的性质随合成条件的不同而有很大差异，因此，以下参数应谨慎控制：pH，浓度，温度，反应物溶液的混合顺序以及老化的条件，钼酸锆沉淀的洗涤和干燥。钼酸锆柱的主要特征是洗脱产率数据。尽管该研究所在该领域的研究工作在过去五年中被搁置，但仍然为该国提供更廉价的Tc-99m核医学应用来源的目标仍然存在。希望使用反应堆生产的Molybenum-99开发新的色谱柱材料能够实现这一目标。

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