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首页> 外文会议>Workshop on the utilization of research reactors >Research Efforts to Produce a ~(99)Mo-~(99m)Tc Generator using Reactor-Produced ~(99)Mo
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Research Efforts to Produce a ~(99)Mo-~(99m)Tc Generator using Reactor-Produced ~(99)Mo

机译：使用反应堆产生的〜（99）Mo产生〜（99）Mo-〜（99M）Tc发生器的研究努力

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Recognizing the importance of ~(99m)Tc and ~(99m)Tc-based radiopharmaceuticals in nuclear medicine, the Philippine Nuclear Research Institute has initiated research on the development of column-type generators for ~(99m)Tc using ~(99)Mo in the form of a gel. The use of reactor-produced ~(99)Mo will reduce the country's dependence on the importation of commercial generators based on fission product molybenum-99. However, the relatively low specific activity of ~(99m)Mo must be compensated by the high adsorption capacity of the column material for molybeneum. A procedure based on the incorporation of low activity ~(99)Mo into a zirconium molybdate gel matrix was adopted with reasonable success. Because the properties of the gel vary considerably with conditions of synthesis, the following parameters were carefully controlled: pH, concentration, temperature, order of mixing of the reactant solutions and conditions of aging, washing and drying of the zirconium-molybdate precipitate. The zirconium molybdate column was characterized mainly by elution yield data. Although the Institute's research work in this area has been shelved in the past five years, the goal of providing the country with cheaper source of Tc-99m for nuclear medical applications remains. It is hoped that the development of a new column material using reactor-produced molybenum-99 will fulfill this goal.
机译：认识到〜（99米）TC和〜（99米）的核医学中的TC〜（99米）的重要性，菲律宾核研究所已经开始研究〜（99米）TC的柱式发电机的开发研究以凝胶的形式。使用反应堆制作的〜（99）Mo将降低该国对基于裂变产品Molybenum-99进口商业发电机的依赖性的依赖。然而，〜（99m）Mo的相对较低的比活性必须通过钼柱材料的高吸附能力来补偿。采用基于低活性〜（99）Mo掺入锆钼酸盐凝胶基质中的过程，具有合理的成功。因为凝胶的性质随合成条件而变化，所以仔细控制以下参数：pH，浓度，温度，混合反应性溶液的混合顺序和抗锆 - 钼酸锆沉淀物的洗涤和干燥。锆钼酸锆柱的特征主要是通过洗脱产量数据的特征。虽然该研究所在该地区的研究工作已经在过去的五年里被搁置，但仍然是为核医学应用提供核医学应用的TC-99M的更便宜来源的目标。希望使用反应堆制作的Molybenum-99的新柱材料的开发将满足这一目标。

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